Abstract 2414: Left Ventricular Functional Analysis Using 64-slice Multi-detector Row Computed Tomography: Comparison with Echocardiography, Cardiovascular Magnetic Resonance and Left ventriculography
PURPOSE: To assess the left ventricular (LV) function using 64-slice multi-detector row computed tomography (CT) and segmental reconstruction algorithm, and to compare with echocardiography, cardiovascular magnetic resonance (CMR) and left ventriculography (LVG).
MATERIALS AND METHODS: A total of 244 patients referred for coronary CT angiography were the source of the retrospective study. Forty patients (33 men; age 68.1±13.5 years; heart rate 69.4±16.0 bpm) who had 64-slice CT and LVG studies within two weeks were enrolled for analysis. Echocardiography was performed in 34 and CMR in 19 of them during the same period. Global parameters were compared by correlation and regression analyses, and systemic error and degree of agreement were assessed with Bland-Altman analysis. Regional wall motion was compared between CT and LVG in a 7-segment and 5-point scale system (from 1=normal to 5=akinesis/dyskinesis).
REULTS: Our results showed a good correlation between ejection fraction (EF) with CT and LVG (r=0.92), CMR (r =0.95) or echocardiography (r=0.88; all P < .0001). There were no significant differences between EF estimated with different modalities. Bland-Altman analysis showed acceptable limits of EF (±11.9%) without systemic errors by using CT in comparison with LVG. The standard deviation of EF difference estimated with CT and CMR was significantly lower than that with LVG (P=0.047), or echocardiography (P < .0001) using CMR as the reference in these 19 subjects. Of 40 subjects, there were 78 segments classified as dysfunctional either by CT or LVG. For the regional wall motion assessment, excellent correlations of the summed scores (r=0.99) and agreement of 95.1% (κ=0.86, range 0.66–0.92) were observed between CT and LVG.
CONCLUSION: LV functional assessment with 64-slice CT correlated well with LVG. Moreover, CT showed superior precision to echocardiography or LVG when compared with CMR.