Abstract 2408: Progression of Coronary Artery Calcification
We sought to determine the progression rates of coronary artery calcium (CAC) in patients undergoing serial scans (at least 3) in order to ascertain the progression patterns over time.
Methods & Results: We evaluated two hundred and ninety four participants with at least CAC ≥10 at baseline who underwent at least 3 CAC scans. The majority of the population were men (59%), mean age was 66 yrs and 48% had hypercholesterolemia. The median (IQR) at baseline (score1) was 221 (84 – 494). 84 (29%) had CAC 10 –99, 112 (38%) had CAC 100 –399 and 98 (33%) had CAC≥400. Participants underwent 2 further scans at least 12 months apart. The inter-scan period from baseline to the first FU (follow-up) was 2.6±1.6 yrs (range 1– 8 years) and from 1st FU to 2nd FU was 2.5±1.3 yrs (1–10 yrs) respectively. The median (IQR) at first FU (score2) is 328 (139 – 661). Forty-four individuals (15%) had CAC 10 –99, 118 (40%) had CAC 100 –399 and 132 (45%) had CAC≥400. Overall the median (IQR) absolute change/yr in 1st FU was 38 (11– 87), and 41 (13–91) in 2nd FU respectively. Similarly, the median (IQR) percent change/yr from scan1–2 was 17% (4 –30), and 13% (5–24) from scan 2–3. In our study population, 70% of individuals had a significant CAC progression (≥15% percent change) in the first FU, whereas 65% had a significant CAC progression in the 2nd FU. Greater duration of FU was significantly associated with the likelihood of progression in both the 1st and the 2nd FU (p<0.0001). Also individuals who progressed in the 1st FU showed a tendency to progress more in the 2nd FU (p=0.07).
Conclusion: In the presence of pre-existing coronary artery calcium, about 70% of individuals show a significant CAC progression (≥15% percent change) in the first FU and 65% demonstrate a significant CAC progression in the 2nd FU. Progression of coronary artery calcium appeared fairly linear over three scan periods, up to 8 years apart.