Abstract 2398: Serum Uric Acid as a Risk Factor for Cardiovascular Disease in Countryside Patients with Essential Hypertension
Objective To examine the association of serum uric acid level with cardiovascular disease and the prevalence of hyperuricemia in Chinese countryside patients with essential hypertension enrolled in the Stroke Prevention by Antihypertensive Drugs (SPREAD) study.
Methods Participants were 5312 hypertensive patients of either sex, aged from 40 –75 years old, living in 7 rural communities in Xinyang county, Henan province. Demographic and vascular risk factors were investigated. Blood sample was drawn for biochemical measurement including serum uric acid, fasting glucose, total cholesterol levels, and serum creatinine.
Results The mean serum uric acid in countryside male and female hypertensive patients were 349.9±80.9 and 266.9±72.2μmol/L, respectively. The overall prevalence of hyperuricemia (defined as serum uric acid levels > or = 416 μmol/L in men or 360 μmol/L in women) was 14.0%, while hyperuricemia was more prevalent in men than in women (21.5%vs10.2%, P<0.001). Hypertensive patients with serum uric acid level in the highest quartile (≥344umol/L ) had higher incidence of coronary artery disease, peripheral artery disease, metabolic syndrome, left ventricular hypertrophy, high serum creatinine level (> 106umol/L) and dyslipidemia than those in the lowest quartile (<231.7umol/L) (P<0.001). After adjusting for age, sex, blood pressure, body mass index, glucose, and treatment history with antihypertensive drugs, hyperuricemia was still associated with increase risk of coronary artery disease (odds ratio [OR] 1.428, 95% confidence interval [CI] 1.113 to 1.832, P<0.005), peripheral artery disease (OR: 1.653, 95%CI: 1.224 to 2.231), left ventricular hypertrophy (OR: 1.382, 95%CI: 1.059 to 1.802), and high serum creatinine level (OR: 10.06, 95%CI: 7.201 to 14.051).
Conclusions Hyperuricemia might be a major contributor to atherosclerosis and target organ damage in countryside hypertensive patients.