Abstract 2390: Metabolic Activity within Periodontal Tissue Correlates with Carotid Plaque Inflammation
Background: Several lines of evidence demonstrate an association between periodontal and cardiovascular diseases. Here we use PET imaging with FDG (a measure of tissue glycolysis) to test the hypothesis that the metabolic activity within periodontal tissues (a likely surrogate for periodontal inflammation) predicts inflammation in a remote atherosclerotic vessel.
Methods: Eleven patients with severe carotid artery stenosis, who were scheduled for carotid endarterectomy (CEA) underwent FDG-PET imaging 3 hours after 18F-FDG administration (13–25 mCi). Periodontal glycolysis (FDG uptake) was measured by obtaining standardized uptake values (SUVs) from the upper and lower gumlines (fig⇓) of each patient, and the ratio of periodontal to background (blood) activity was determined (TBR). Localization of carotid and periodontal activity was facilitated by PET co-registration with CT images. Less than one month after PET imaging, subjects underwent CEA, during which the atherosclerotic plaques were removed and subsequently stained with anti-CD68 antibodies to quantify macrophage infiltration. Periodontal FDG uptake was compared with plaque macrophage infiltration for each patient.
Results: The average periodontal TBR strongly correlated with histologically-assessed inflammation within the excised carotid plaques for each patient, (R=0.75, p<0.008).
Conclusion: FDG-PET measurements of metabolic activity within periodontal tissue correlate with and may be predictive of macrophage infiltration within carotid plaques. These findings further support the association between periodontal and atheroscleotic diseases.