Abstract 2369: The Circulating Levels of Heart-Type Fatty Acid-Binding Protein (H-FABP) and Brain Natriuretic Peptide (BNP) in General Japanese Population: Effects of Age, Sex, and Other Physiologic Characteristics
Background: For the precise assessment of reference values, it is important to know biological variations. Although it has been reported that H-FABP, a new marker for myocardial cell injury, and BNP, a marker for cardiac loading conditions, provide prognositic information in heart failure, the impact of age, sex, and other physiologic characteristics on these markers are not fully understood. In this study, we examined physiological variations of these markers in a large general population.
Methods and Results: We measured these markers in 2099 subjects (men 933, women 1166, age 40–87) at annural healthy check-up. Plasma BNP levels were higher in women compared to men. Serum H-FABP levels were higher in men compared to women. H-FABP and BNP levels increased with aging (Figure⇓). Multiple logistic regression analysis showed that increased H-FABP and BNP levels were influenced by various factors (Table⇓).
Conclusion: Our study indicated in a large general population that H-FABP and BNP levels are affected by physiologic factors. These effects should be taken into account in determining appropriate reference values and identifying patients with heart diseases in clinical practice. Since elevated H-FABP levels are associated with aging, renal dysfunction, hypertension, and ECG abnormality, H-FABP may represent latent cardiac diseases and have important clinical implications.