Abstract 2354: Carotid Arterial Stiffness is an Independent Predictor for Left Ventricular Diastolic Dysfunction in Patients with Cardiovascular Risk Factors
Background: It is well known that arterial stiffness correlates with mortality or prevalence of cardiovascular disease. However, there are limited data on correlation between arterial stiffness and left ventricular (LV) diastolic function in patients with cardiovascular risk factors.
Methods: We recorded regional myocardial strain profiles at the mid-portion of the LV posterior and inferior walls on the parasternal LV short-axis view in 30 patients (16 men and 14 women, aged 57±8 years) with one or more risk factors and with no previous cardiovascular disease. LV diastolic function was were determined by measuring transmitral flow velocity, mitral annular motion velocity, and myocardial strain and strain rate profiles. The diameter of common carotid artery was measured at end-diastole and end-systole (Dd and Ds, respectively). Arterial stiffness index (β) was calculated from the following formula: β= ln (SBP/DBP)/[(Ds-Dd)/Dd], where SBP and DBP denote the systolic and diastolic blood pressure , respectively.
Results: The β was greater, and peak early diastolic strain rates of the LV posterior and inferior walls were lower in the patients than in the controls. The β correlated with age, peak early diastolic velocity and the deceleration time of the transmitral flow, peak early diastolic mitral annular motion velocity, and peak early diastolic strain rates of the LV walls. Multiple linear regression analysis revealed that early diastolic strain rates of the LV walls are strongly related toβ.
Conclusion: LV relaxation was associated with carotid arterial sclerosis in subclinical patients with cardiovascular risk factors. These results support the importance of screening using ultrasonic strain imaging and early intervention in this patient population.