Abstract 2338: Prevalence and Prognostic Significance of Wall Motion Abnormalities in Adults without Recognized Cardiovascular disease: The Strong Heart Study
Left ventricular wall motion (WM) abnormalities have recognized prognostic significance in patients with coronary heart disease. Aim of the study was to determine whether echocardio-graphic WM abnormalities predict subsequent cardiovascular (CV) events in a population-based sample of adults without overt CV disease.
Methods: Participants (n=3,070) without known CV disease in the 2nd Strong Heart Study examination, who had complete 2-dimensional echocardiographic WM assessment were studied. Relationships between WM abnormalities and fatal and non-fatal CV events (including myocardial infarct, stroke, coronary artery disease and heart failure; n= 592) and CV mortality (n= 143) during 7±2 years follow-up were examined.
Results: Overall, 161 participants (5%) had segmental WM abnormalities. In univariate proportional hazard analyses, segmental WM abnormalities were associated with 3.4-fold higher risk of first CV events (95% confidence interval [CI] 2.6 to 4.4, p<0.0001) and with a 3.9-fold higher risk of CV death (95% CI 2.4 – 6.2, p<0.0001) (Figure⇓). In multivariate Cox regression models, controlling for relevant covariates, segmental WM abnormalities were associated with a 2.7-fold higher risk of CV events (95% CI 2.1–3.6, p<0.0001) and with 2.5-higher risk of CV mortality (95% CI 1.5– 4.2, p < 0.0001).
Conclusion: Echocardiographic left ventricular WM abnormalities in subjects without overt CV disease are associated with 2.5 to 2.7-fold higher risks of CV morbidity and mortality, independent of established risk factors.