Abstract 2315: Prognostic Impact of Type 1 Brugada ECG at Higher (3rd or 2nd) V1 - V2 Recording in Brugada Syndrome
Introduction: ECG recorded at higher (3rd or 2nd) intercostal space is recommended to detect Type 1 Brugada ECG. However, its systematic evaluation in relation to its prognostic value has not been done.
Hypothesis: We assessed the hypothesis that prognostic value of higher ECG recording is as same as that of standard ECG.
Methods: The study population consisted of 100 patients (pts) (98 males, 17 – 76 (47 ± 14) years, documented ventricular fibrillation (VF) 23 pts, syncope only 33 pts) with Type 1 Brugada ECG recorded in V1-V2 leads at standard (4th) and/or higher (3rd or 2nd) intercostal space. They were divided into 3 groups; 69 patients with spontaneous Type 1 ECG at standard V1-V2 leads (S group), 20 patients with spontaneous Type 1 ECG only at higher V1-V2 leads (H group), and 11 patients with Type 1 ECG only after Ic sodium channnel blockers (Ic group).
Results: There were no significant differences in baseline clinical characteristics including presence of VF episode, syncope, atrial fibrillation, family history, late potentials, and inducibility of VF during EPS between the 3 groups. During prospective follow-up period (789 ± 528; 422 ± 291; 573 ± 382 days, respectively), subsequent cardiac events occurred in 11 (16%) patients with S group, in 3 (15%) patients with H group, and in no (0%) patients with Ic group (figure⇓, p=NS; S vs. H group). Among patients with previous episodes of VF, subsequent cardiac events occurred in 7 (44%) patients with S group and in 3 (60%) patients with H group (p=NS).
Conclusion: Patients with spontaneous Type 1 Brugada ECG recorded only at higher V1-V2 leads showed similar prognosis as those with Type 1 ECG at standard V1-V2 leads.