Abstract 2306: Long-Term Follow-up of Electrocardiographic Features in Patients with Brugada Syndrome: Comparison between SCN5A Mutation Carriers and Non-Mutation Carriers
Background: Mutations in SCN5A gene, which encodes α-subunit of the cardiac sodium channel, has been reported to be linked to Brugada syndrome. However, electrocardiographic changes with aging and its relation to SCN5A gene mutation are unknown in patients with Brugada syndrome (BS).
Method: Electrocardiographic parameters were prospectively followed up for more than 5 years in 8 BS probands with SCN5A mutation (SCN5A positive group: all males, 46 ± 10 y.o. at early period, Follow-up duration 10 ± 5 years) and 36 BS probands without SCN5A mutation (SCN5A negative group: all males, 46 ± 13 y.o. at early period, Follow-up duration 10 ± 4 years; P=N.S vs. SCN5A positive group, respectively).
Depolarization parameters, such as P wave (II), QRS (V2), S wave (II) durations, and PQ interval (II) were all significantly longer and S wave (II) amplitude was significantly deeper in the SCN5A positive group than in the SCN5A negative group throughout the follow-up period
The SCN5A positive group showed significantly longer QTc interval (V2) and higher ST amplitude (V2) in the SCN5A positive group at both early and late periods, and
most of depolarization parameters were significantly increased with aging during follow-up period in both groups, however, the PQ interval (II) and QRS duration (V2) were more prominently prolonged, and the QRS axis was more deviated to the left in the SCN5A positive group than in the SCN5A negative group.
Conclusions: Depolarization parameters and repolarization parameters in the right precordial lead were longer in Brugada probands with SCN5A mutation than those without SCN5A mutation, some of which were more progressively increased with aging.