Abstract 2283: Can C-reactive Protein predict the Delirium in Patients with Acute Myocardial Infarction and Acute Aortic Dissection during Intensive Care Unit Stay?
It has been hypothesized that activated inflammatory process in the central nerve system play an important role in the occurrence of delirium. Several studies reported the frequent occurrence of delirium in patients hospitalized in (ICU). However, the association between inflammatory markers and delirium in patients with acute myocardial infarction (AMI) and acute aortic dissection (AAD) in intensive care unit (ICU) remain unknown.
Aim: To examine whether systemic inflammation is correlated with transient delirium in AMI and AAD.
Subjects: Consecutive 118 cases of AMI and 144 cases of Stanford type B AAD hospitalized for medical treatment within 24 hours of onset were enrolled in this study.
Methods: All patients’ medical records were retrospectively evaluated for the presence of transient delirium during ICU stay according to the delirium scale. Multiple regression analysis was done using following factors as independent: age, sex, smoking, drinking, duration of ICU stay, maximum serum C-reactive protein (CRP) level, minimum oxygenation index and body mass index.
Results: Delirium was diagnosed in 18 of 118 in AMI and 74 of 144 in AAD (15.1% vs. 51.4%, p<0.01). Multivariate analysis showed that age (p<0.005) and CRP level (p<0.01) were independent predictors of delirium in AMI, on the other hand smoking (p<0.01), age (p<0.005) and CRP level (p<0.01) were independent predictors in AAD.
Conclusion: Systemic inflammation is a potent predictor for the delirium in AMI and AAD. These suggest that an anti-inflammatory strategy might be effective for prevention of delirium in this disorder.