Abstract 2265: The Balance of n6/n3 Polyunsaturated Fatty Acid (PUFAs) is an Important Determinant Factor of Prognosis after Acute Myocardial Infarction
Aim: We have reported that a balance of n6/n3 PUFAs, particularly a ratio of arachidonic acid (AA) to eicosapentaenoic acid (EPA), is positively related to the amount of unstable coronary plaque by the studies with both coronary angiographies and coronary CT angiographies. In this study, we examined whether a higher ratio of AA to EPA is related to worse prognosis after the onset of acute myocardial infarction(AMI) or not.
Method: A total of 269 consecutive AMI patients were enrolled in this study. On the day of admission, we examined both classical coronary risk factors (T.Cho, TG, HDL-C, LDL-C, Uric acid, Blood glucose, Hb-A1c) and four fractions of PUFAs (di-gamma-linoreic acid, AA, EPA and docosahexaenoic acid (DHA)). Major adverse cardiac events (MACE), including death, recurrence of angina, repeated PCI, CABG and readmission due to heart failure, were analyzed for up to 4.8 years (average 269+−494 days). We used Kaplan-Meier method for statistical analysis.
Results: We divided patients into three groups by the ratio of AA to EPA; less than 2 (n=90;group A), 2 to 3 (n=80;group B) and more than 3 (n=99;group C). The group C had significantly higher MACE than other groups (p=0.014, Fig⇓). The ratio of AA to EPA had no significant correlation to classical coronary risk factors, indicating it is an independent risk factor.
Conclusion: The balance of n6/n3 PUFAs is an important and independent coronary risk factor to determine the prognosis after AMI in Japanese patients.