Abstract 2261: Skin Autofluorescence Predicts One Year Incidence of Major Adverse Cardiac Events after Acute Myocardial Infarction
Introduction: STEMI is associated with increased inflammation and oxidative stress, enhancing the formation of Advanced Glycation End products (AGEs). Some AGEs encompass a characteristic fluorescence pattern, which can be non-invasively measured as skin autoflourescence (AF). Skin AF is elevated in STEMI, but no prospective data are available.
Aim: A prospective study to investigate if skin AF predicts the one year incidence of major adverse cardiac events (MACE) in patients with STEMI.
Methods: Skin AF was assessed on the lower arm within 72 hours after admission and was defined as the mean of emitted light intensity (420 – 600 nm) divided by mean of the excitation light intensity (300 – 420 nm). Exclusion criteria were impaired renal function, infection, or skin photo type V/VI.
Results: Eighty-eight patients were included (age: 64 ± 13 years; 76% male; smoking: 41%; diabetes: 28%; previous MI: 7%). During follow-up, MACE occurred in 11 subjects (death: 4; myocardial infarction: 4; heart failure: 3). The optimal cut-off value for skin AF was calculated as ≥2.6 arbitrary units (area under the curve, 0.76; 95% CI, 0.66 – 0.85; P<0.001). The figure⇓ demonstrates that skin AF was an independent predictor of MACE.
Conclusion: These data demonstrate that skin AF, a non-invasive measure for AGEs, independently predicts future events in patients with STEMI, making it a promising tool for assessing risk of complications following STEMI.