Abstract 2234: Obesity and Risk of Ventricular Arrhythmias in Patients with Left Ventricular Dysfunction
BACKGROUND: Aim of our study was to evaluate the risk of ventricular tachyarrhythmias and sudden death by body mass index in post infarction patients with severe left ventricular dysfunction.
METHODS: Post infarction patients with left ventricular dysfunction enrolled in ICD arm of MADIT II were categorized as those with (BMI ≥ 30 kg/m2) and without (BMI < 30kg/m2) obesity. Patients with diabetes were excluded from the analysis. Prognostic significance of obesity was evaluated in separate multivariate models with each of the following end points: ventricular tachyarrhythmias (VT/VF), VT/VF or sudden cardiac, and non-sudden death.
RESULTS: Mean BMI was 27+/−5 kg/m2; there were 120 patients (25%) with, and 356 (75%) without, obesity. Predictive models were adjusted for significant clinical variables: NYHA class ≥III, age ≥ 65 y/o, and body urea nitrogen (BUN). As shown in the Table⇓ and graph below, obese patients had significantly increased risk of VT/VF documented by ICD interrogation as well as increased risk of VT/VF or sudden cardiac death. Non-sudden death (dominated by pump failure death) was not associated with obesity.
CONCLUSIONS: Our analysis of MADIT II patients showed that obese individuals have increased risk of arrhythmic events. There was no association between obesity and non-arrhythmic mortality.