Abstract 2155: Global and Regional Myocardial Function Quantification by Two-dimensional Strain (2D-Strain): Application in Top Level Athletes and in Patients with Hypertrophic Cardiomyopathy
Introduction: Strain imaging has been proposed as a sensitive tool to detect early systolic dysfunction in HCM. Two-dimensional strain (2D-Strain) is a novel method to measure strain from standard two-dimensional echocardiographic images. The aim of our study was to characterize global and regional function abnormalities using this technique in top level athletes (German national handball league) and in patients (pts.) with pathological left ventricular hypertrophy (LVH) caused by nonobstructive hypertrophic cardiomyopathy (HCM).
Methods: 16 consecutive athletes and 15 HCM-pts. were studied by echocardiography according to ASE guidelines. Global Longitudinal Strain (GLS) and regional peak systolic strain (PSS) was assessed by 2D-Strain in the apical four-chamber-view using a dedicated software package (Vivid 7, GE Healthcare).
Results: Mean enddiastolic thickness of septum was significantly increased in the HCM-group (18±6mm vs. 11±1mm; p<0.01). Mean LV enddiastolic index was 27±3 and 25±4 cm/m2 (n.s.). Mean GLS was −8.1±3.8% in the HCM-group and −13.4±3.1% in the athletes (p<0.01). Pts. with HCM showed decreased longitudinal PSS in the septal segments (basal: −6.1±4.3% vs. −13.7±2.7%, p<0.01, mid: −8.3±4.2% vs. −17.6±2.4%, p<0.01; apical: −12.2±5.3% vs. −19.5±6%; p<0.05) and in the lateral segments (basal: −8.4% vs. −17.0%, p< 0.05; mid: −6.9% vs. −11.0%, n.s.; apical: −7.6% vs. −18.2%, p<0.01).
Conclusion: Two-dimensional strain is a simple and rapid method to measure GLS and PSS. This technique might be used as new helpful tool for the differentiation between physiologic and pathologic LVH.