Abstract 2094: Cardiovascular Risk Factors and Metabolic Syndrome in Alcohol-Dependent Men and Women
Background: Cardiovascular disease (CVD) is a leading cause of mortality among alcoholics; however, minimal data exist on the CVD risk factor profile in this high-risk population. The purpose of this study was to examine the prevalence and clustering of traditional and novel CVD risk factors including components of the metabolic syndrome (MetS) in nicotine and alcohol dependent adults.
Methods: Participants (n=46; 61% Male; 87% Caucasian), who were a consecutive series of eligible adults (19 –56 yrs. of age; M= 34.8+/− 10 yrs.; DSM IV classified alcoholic; abstinent for </= 7 days), were assessed on entry to a residential drug treatment facility. CVD risk factors were measured using standardized protocols and interview-administered, self-report inventories adapted from epidemiologic studies. Dyslipidemia and MetS were identified using ATP III criteria; hypertension was classified by JNC VII criteria. Enzymatic colorimetric and immunocheminoluminometric techniques were used to measure plasma lipids and homocysteine (Hcy) and high-sensitivity C- reactive protein (hs-CRP), respectively.
Results: Dyslipidemia was identified in 74% of participants; fifty % were overweight or obese (BMI >/=25 kg/m2 ); 61% were physically inactive (< 1000 kCal/week), and 61% had some form of hypertension. In addition, 54 % had increased Hcy values; hs-CRP was elevated in 28%; 22% of the participants met criteria for MetS.
Conclusion: In this study, of the CVD risk profile among alcoholics, subjects were found to have an average of 3 CVD risk factors. Although the sample size was limited, a strength of this study was that all the data was collected on newly abstinent patients entering a treatment facility. This prevalence and clustering of potentially modifiable risk factors in young, nicotine-dependent alcoholics indicates the need for aggressive risk reduction focused on primary prevention of CVD. Finally, the findings from this investigation, merit further study in diverse samples of alcohol-dependent adults.