Abstract 1974: Comparisons of Ultrasound Radio Frequency Analysis between Integrated Backscatter Intravascular Ultrasound and Virtual Histology Intravascular Ultrasound for Tissue Characterization of Coronary Plaques
Background: We recently developed the commercially available Integrated Backscatter (IB) Intravascular Ultrasound System for tissue characterization of coronary plaques. However, comparisons between IB-IVUS and Virtual Histology (VH) IVUS images for tissue characterization have not been precisely investigated.
Methods: Images were acquired from 150 segments of 46 coronary arteries from 25 cadavers obtained at autopsy. To clarify the rotational and cross sectional position of the included segments, many surgical needles were inserted transversely through these coronary arteries. One hundred fifty diseased coronary arterial segments were examined for comparison of IB-IVUS and VH-IVUS images at the same exact sites. Histological examinations were also performed. Only the segments in which the diagnoses were identical between the two IVUS readers were used for comparison with histology.
Results: The two IVUS readers made identical diagnoses in 138 segments using the IB-IVUS and in 133 segments using the VH-IVUS. The inter-observer agreements of IB-IVUS and VH-IVUS for characterization of plaque type were excellent (Cohen’s κ = 0.90 and 0.85). According to the definition of atherosclerotic lesions by the AHA Council on Atherosclerosis (III, IV, Va, Vb, Vc), the overall agreement between histological and IB-IVUS diagnoses was higher (κ = 0.81) than that of VH-IVUS diagnoses (κ = 0.66) in the same segment.
Conclusion: The commercially available IB-IVUS system provides high diagnostic potential for analysis of tissue characteristics of coronary plaques.