Abstract 1968: Volumetric Plaque Characterization Analysis of Target Lesion in Patient with Coronary Intervention: Comparative Study of Integrated Backscatter Intravascular Ultrasound and 64-Slice Multi Detector Computed Tomography
Background: There are few data about quantitative evaluation of coronary plaque characterization using various modalities. The aim of this study is to compare quantitative plaque characterization using multi detector computed tomography (MDCT) and integrated backscatter intravascular ultrasound (IB-IVUS) which demonstrated useful tool for detection vulnerable plaque.
Methods: 56 consecutive patients who performed elective coronary intervention after MDCT and IB-IVUS were enrolled. Volumetric plaque characterization analysis of target lesion was evaluated. In MDCT analysis, (Fig. A⇓) each plaque components were defined as soft (~60HU), fibrous (60~150HU) and Calcific (500HU~). In IB-IVUS analysis, (Fig. B⇓) color coded maps of tissue characteristics of each 1mm slice in target lesions were constructed and volume of each plaque components (calcification −11~−29dB, fibrous −29~−49dB and lipid core ≤ 49 dB IB-value) was calculated using Simpson’s method.
Results: Table1,2 shows relation of volume and fraction (volume of each component /total plaque volume) of each plaque component using MDCT and IB-IVUS. There is a positive correlation between total plaque volume derived from MDCT and IB-IVUS (r = 0.62, p < 0.0001 ) and volume of each component (Table1). There is positive correlation between fraction of each component from MCTD and corresponding components from IB-IVUS (Table2).
Conclusions:Volume and fraction of each plaque components derived from MDCT correlate corresponding plaque component derived from IB-IVUS.MDCT provide similar information about tissue characterization derived from IB-IVUS and may be non invasive tool to detect plaque vulnerability.