Abstract 1855: Effects of Aging on Left Ventricular Dyssynchrony and Diastolic Function
Background: Left ventricular (LV) diastolic filling declines with aging in normal subjects. Tissue Doppler echocardiography can detect ventricular dyssynchrony by comparing tissue velocities at multiple sites. We investigated the influence of aging on LV systolic and diastolic dyssynchrony and global LV diastolic function in normal subjects.
Methods: We studied 67 subjects (mean age 56±16, range 26 to 79 years) without significant coronary and valvular heart diseases. Echocardiography was performed and a serum BNP level was measured in all subjects. On color tissue Doppler imaging, LV systolic and diastolic dyssynchrony was defined as the standard deviation of the time to peak systolic velocity (Ts-SD) and the time to peak early diastolic velocity (Te-SD) among 12 LV segments (6 basal and 6mid), respectively.
Results: The mean Ts-SD was 27±16 ms and Te-SD was 20±11 ms. With advancing age, early diastolic filling was decreased (r=−0.35, P<0.01) concurrently with the reduction of E/A ratio (r=−0.53, P<0.01). BNP increased with aging (r=0.50, P<0.01). There was no relation between age and Ts-SD (r=−0.21, P=NS). However, Te-SD increased significantly with advancing age (r=0.39, P<0.01). These results were not changed with correcting for heart rate. By using multivariate analysis, Te-SD significantly contributed to LV filling in normal subjects.
Conclusion: The degree of LV diastolic dyssynchrony increased with aging. Increased LV diastolic dyssynchrony was associated with the physiological decline of LV diastolic filling and elevation of BNP.