Abstract 1848: Quantitative Assessment of Right Ventricular Volume and Function with Real-time three-dimensional Echocardiography: Comparison with Cardiovascular Magnetic Resonance
Background: Cardiovascular magnetic resonance (CMR) has been successfully used as an accurate and reproducible tool to quantify right ventricular (RV) volumes in both normal and pulmonary arterial hypertension (PAH) subjects. Real-time three-dimensional echocardiography (RT-3DE) has emerged as an attractive modality for measurement of left ventricular function but its accuracy for RV assessment has not yet been validated. The aim of this study is to compare RT-3DE and CMR, in the RV assessment, in patients with PAH and healthy subjects.
Methods: We studied 14 PAH patients paired with 6 normal controls. CMR imaging was performed on a high field 3.0-Tesla. Calculation of the end-diastolic (EDV), end-systolic (ESV) volumes and ejection fraction (EF) from the echocardiographic data were performed using dedicated offline software.
Results: The RT-3DE data correlated highly with CMR in all variables tested (EDV: r=0.96 p<0.001, ESV: r=0.93 p<0.001 and EF: r=0.86 p<0.001). However, RV volumes were underestimated by RT-3DE compared with CMR (EDV −27.5 ± 14.4 ml, p = 0.002; ESV −17.3±14.3 ml, p = 0.004). The difference for EF was not significant between the two methods (EF −1.1±13%, p =0.79). Intra- and interobserver agreement was good for both techniques.
Conclusions: The RT-3DE is a fast and reproducible technique which allows accurate determination of RV cardiac volumes and function compared with CMR. Larger studies are needed in order to further validate this novel modality.