Abstract 1842: Reproducibility and Accuracy of Left Ventricular Mass Measurements with Real-Time Three-Dimensional Echocardiography: Comparison with Magnetic Resonance Imaging.
Purpose. Left ventricular (LV) mass is an important predictor of morbidity and mortality. Because the reproducibility of LV mass measurements is far better with cardiac magnetic resonance (cMR) than with 2D-echo, cMR has become the reference method. The aim of this study is to test the accuracy and the reproducibility of real-time 3D-echocardiography (RT-3DE) in comparison with cMR.
Methods. 51 pts with normal or abnormal LV function were evaluated by RT-3DE and cMR. RT-3DE LV mass data were analyzed using a prototype version of the QLab software that allows for semi-automatic detection of endocardial and epicardial borders and calculation of LV mass from voxel counts. With cMR, LV mass was calculated by manually tracing endocardial and epicardial borders on short-axis slices. All measurements were made twice by 2 different observers. A day-to-day reproducibility was also performed.
Results. RT-3DE and cMR measurements of LV mass were highly correlated (r = 0.93) and not significantly different from each other (145 ± 42g vs 146 ± 45g, p = 0.7). Intertechniques bias was −1 ± 35g. RT-3DE and cMR showed excellent interobserver agreement as illustrated by the small absolute (−1± 34g for RT-3DE, 2 ± 24g for cMR) and relative (9 ± 9g for RT-3DE, 8 ± 6g for cMR) interobserver bias. 5 pts underwent RT-3DE and cMR twice on 2 days. LV mass by both techniques were similar on both days (p=NS), with small bias (3 ± 9g vs 0 ± 8g).
Conclusion. RT-3DE allows for the accurate determination of LV mass, when compared to cMR. In addition, RT-3DE measurements of LV mass are as reproducible as those obtained with cMR. This suggests that RT-3DE can be used in the follow-up of patients with LV hypertrophy and/or remodelling.