Abstract 1814: Metabolic Syndrome Increases Operative Mortality in Patients Undergoing Coronary Artery Bypass Grafting Surgery
Background: Diabetes and obesity are highly prevalent among patients undergoing coronary artery bypass grafting surgery (CABG). However, it remains unclear whether these factors have a significant impact on operative mortality following this procedure. We hypothesized that the metabolic abnormalities associated with the metabolic syndrome (MS) could negatively influence the operative outcome of CABG surgery.
Methods: We retrospectively analyzed the data of 5304 consecutive patients who underwent isolated CABG procedure between 2000 and 2004. Of these 5304 patients, 2411 (46%) patients met the NCEP-ATPIII criteria for the MS. The primary end-point was the operative mortality.
Results: The operative mortality following CABG surgery was 2.4% in patients with the MS and 0.9% in patients without the MS (p < 0.0001). Multivariate analysis revealed that the MS was a strong independent predictor of operative mortality RR 3.04 [95% CI: 1.76–5.25], (p < 0.0001). However, diabetes was not an independent predictor of operative mortality but diabetic patients with the MS had an increased operative mortality (RR 2.7; p = 0.002).
Conclusion: This is the first study to report that the MS is a highly prevalent and powerful risk factor for operative mortality in patients undergoing a CABG surgery. Considering such high prevalence of the MS among the surgical population undergoing CABG, interventions aimed at reducing the prevalence of the MS before surgery would have an important positive impact.