Abstract 1796: Impact of Vacuum Assisted Venous Return and of Processing of Pericardial Blood with a Cell Saver Device on Postoperative Inflammatory Response: A Prospective Randomized Study
Objective: Vacuum assisted venous return (VAVR) and processing pericardial blood with a cell saver (CS) have been reported to be useful blood sparing. The objective of the present study was to determine whether VAVR and CS entailed reduction of postoperative inflammatory response.
Methods: One hundred patients, who underwent on-pump coronary artery bypass graft surgery, were included in a prospective randomized study. Patients were randomized into 4 groups of 25 patients each in a 2X2 factorial design: Group A had no VAVR and no CS, Group B had VAVR alone, Group C had CS alone and Group D had VAVR and CS. The complement factors C3a, C4a, C5a, the terminal complex sC5b9, and CRP levels were measured in EDTA plasma preoperatively, 30 and 240 minutes after the end of cardiopulmonary bypass (CPB).
Results: Mean age, cardiopulmonary bypass and clamping times were similar in all groups. At 30 and 240 minutes after CPB, C3a and sC5b9 (Table 1⇓) levels were markedly increased, - and C5a and CRP levels decreased - compared with preoperative levels. There were no differences between groups except for lower CRP levels in the absence of CS compared with preoperative and 240 postoperative values.
Conclusion: The present study shows that modern CPB remains associated with a striking activation of complement and of the terminal component. This activation was not influenced with neither VAVR nor CS.