Abstract 1722: Short-term Statin Therapy is Associated with Marked Reduction of Inflammatory Reaction and MMPs of Aortic Plaque in Patients with Abdominal Aortic Aneurysm
Background: Abdominal aortic aneurysms (AAA) accumulate inflammatory cells and matrix metalloproteinases (MMPs), which are implicated in AAA formation. Statins are known to reduce inflammatory reaction and MMPs levels. The aim of this study was to investigate the inhibitory effect of atrovastatin on inflammatory cell infiltration and MMPs levels in human tissue of AAA.
Methods: Patients with AAA were randomized to atorvastatin (20 mg/day, 10 patients) or control (10 patients). After an average treatment of 4 weeks, patients underwent abdominal aorta replacement, tissue specimens were obtained, and the tissue composition was determined by immunohistochemistry.
Results: In atorvastatin pre-operatively group, serum LDL-C level was significantly decreased by 40% whereas there was no significant difference in control group. Atorvastatin reduced the T-cell content (CD3), but did not change lipid, collagen, smooth muscle cell, or macrophage content (CD68). Aneurysm wall from atorvastatin group had less expression of matrix metalloproteinase (MMP)-2&9.
Conclusion: Atorvastatin treatment reduced the T-cell content and the expression of MMPs in human abdominal aortic aneurysm wall.