Abstract 1635: Effect Of Apo A4 A5inter (−12238T>C) Single Nucleotide Polymorphism on Postprandial Metabolism in Normolipidemic Persons
Background: Apo A-V is an important determinant of triglyceride metabolism. A single nucleotide polymorphism (SNP) located in the intergenic region A-IV/A-V (−12238T>C), can affect lipid metabolism.
Aim: We investigated the effect of this SNP on the postprandial lipaemia after a fat meal.
Methods: 84 normolipidemic young men (32TT, 38TC, 14CC) received a 4 week stabilization saturated fat rich diet, followed by a fatty meal containing 1gr fat/Kg of body weight, 60.000 UI of vitamin A per m2 and 7mgr of cholesterol/Kg of weight), with 60% of calories as fat, 15% as proteins and 25% as carbohydrates. Blood samples were taken at time 0 and every hour until the 6th and every 2 hr and 30 min until the 11th after the meal. Total cholesterol (C) and triacylglycerols (TG) in plasma and triacylglycerol rich lipoproteins (TRL) (large TRL and small TRL) were determined.
Results: Postprandial response were higher in TT versus the carriers of the minor allele (TC/CC) in TG in plasma (p=0,002), large TRL-TG (p=0,015), large TRL-C (p=0,0001) and small TRL-C (p=0,041). No differences were found in small TRL-TG or total C.
Conclusions: Carriers of minor allele for Apo A-IV/A-V (−12238T>C) have a lesser postprandial lipaemia compared to homozygotes for the most frequent allele. Our results identify a population with an enhanced postprandial lipid clearance.