Abstract 244: Differential Production of Adiponectin and C-Reactive Protein in Coronary Circulation of Patients with or without Coronary Artery Disease
Background: The adipocyte-specific plasma protein, adiponectin, was originally isolated from human adipose tissues. Adiponectin has anti-atherosclerotic properties and is one of the important adipocytokines linking coronary artery disease (CAD). Recently, it was reported that epicardial adipose tissue expresses adiponectin, levels of which are significantly lower in patients with, than without severe CAD. We previously reported that adiponectin is significantly increased through coronary circulation in patients with angiographically normal coronary arteries. However, whether the plasma level of adiponectin in the coronary circulation varies with the presence of CAD remains unknown. We therefore investigated the relationship between the presence of CAD and the amount of adiponectin produced in the coronary circulation, and evaluated the transcoronary difference in C-reactive protein (CRP) levels in patients with or without CAD.
Methods: Plasma adiponectin and CRP levels at the orifice of the left coronary artery (CA) and in the great cardiac vein (GCV) were measured in 16 patients without CAD and 26 patients with CAD. The difference in plasma adiponectin or CRP levels between GCV and CA was defined as plasma adiponectin or CRP level at GCV minus that at CA.
Result: Plasma adiponectin levels at GCV were significantly higher than those at CA in patients with (median 5.20 vs. 4.90 μg/mL, p<0.001) and without (median, 6.90 vs. 6.25 μg/mL, p<0.005) CAD. The transcoronary difference in plasma adiponectin levels was significantly lower in patients with, than without CAD (median, 0.25 vs. 0.70 μg/mL, p<0.05). On the other hand, the transcoronary difference in plasma CRP levels was significantly higher in patients with, than without CAD (median, 0.90 vs. 0.25mg/L, p<0.05).
Conclusion: Adiponectin is produced in the coronary circulation independently of CAD but levels of plasma adiponectin were significantly lower and those of CRP were significantly higher in patients with, than without CAD. Locally produced adiponectin might, at least in part, contribute to suppressing the initiation and progression of coronary atherosclerosis in an autocrine or paracrine manner.