Abstract 812: Adipocytokines and Proinflammatory Markers Derived From Omental, Pericardial and Subcutaneous Adipose Tissues and Plasma in Patients With and Without Coronary Artery Disease
Background Adipose tissue (AT) may contribute to the inflammatory burden mediated by adipocytokines in coronary arteriosclerosis (CA). Both omental and pericardial AT was reported to play a role in CA. We sought to compare the differences of proinflammatory markers and adipocytokines derived from omental, pericardial and subcutaneous AT and plasma in pts with and without coronary artery disease (CAD).
Methods and Results Samples of omental, pericardial and subcutaneous AT were harvested in 46 pts (37 men, 64±9 years) with CAD for bypass surgery and in 12 non-CAD pts (9 men, 49±14 years) for other open heart surgery (including valve replacement and patch repair of ASD and VSD) after protein release over 3 hours. Local concentrations of adipocytokines (adiponectin, leptin and visfatin) and proinflammatory markers (interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α)) were determined by ELISA. Compared with pts without CAD, IL-6, TNF-α, leptin and visfatin were significantly higher in any sort of AT from pts with CAD. In addition, in pts with CAD, significantly higher levels of all these markers were found in omental followed by pericardial and the lowest in subcutaneous AT. Conversely, adiponectin was significantly reduced in all the 3 selected AT in patients with CAD. Additionally, adiponectin was the lowest in omental followed by pericardial and subcutaneous AT. In patients with CAD, no significant correlation could be demonstrated in any markers between plasma and omental AT expression. However, only plasma level of adiponectin had positive correlation with that of pericardial AT expression (r=0.384, p < 0.05).
Conclusions Adipose tissues might play an important role in CA. The stores of adipocytokines and proinflammatory markers were highest in omental followed by pericardial and the lowest in subcutaneous AT.