Abstract 744: Vortex Filament Characteristics During Atrial Fibrillation Induced by Pulmonary Vein Ectopic Foci Firings
Background - Due to complex atrial anatomy, current mapping techniques can provide only limited information about wavelet characteristics during atrial fibrillation (AF). Possible dynamical wave break during AF is especially hard to monitor across the atrial wall and in the septum region.
Methods - We studied AF induced by spontaneous firings of pulmonary vein ectopic foci in an anatomically accurate three-dimensional atrial model (panel A; left atrium: LA, right atrium: RA). Vortex filaments, which represent the number of wavelets, were detected by calculating the intersection of two successive isovoltage lines (−30 mV) arising from the propagating wave front.
Results - AF was characterized by multiple vortex filaments, reflecting the multiple-wavelet nature of AF. Vortex filaments (red) were found dispersed across the walls of the LA, RA and, even inter-atrial septum region (panel A), indicating wave fragmentation and formation in these regions. Moreover, the number of vortex filaments during the lifespan of an episode of AF (panel B) varied from as few as 1 to as many as 9. The peak number is comparable to that observed in direct mapping studies. However, the pattern of a single and constant driving rotor leading to multiple wavelets was not observed in the pulmonary vein region or anywhere else.
Conclusions - Wavelet characteristics during AF induced by pulmonary vein ectopic foci firings were, for the first time, provided by detecting vortex filaments. Our results may help illuminate the mechanism of AF induced by pulmonary vein ectopic foci.