Abstract 50: Risk factors for Primary Ventricular Fibrillation during Acute Myocardial Infarction: A Systematic Review and Meta-analysis.
Aims To evaluate potential risk factors for primary ventricular fibrillation (PVF) during acute myocardial infarction (AMI) by a systematic review and meta-analyses.
Methods and results We searched in PubMed for “English” articles published between 1964 and Jan 2006 using a validated combination of MESH terms. Twenty-one cohort studies, describing 57158 patients with AMI were analysed. Patients with validated PVF (n = 2316) were characterized by an earlier admission (weighted mean difference −2.62 hours), male gender (OR 1.27), smoking (OR 1.26), absence of history of angina (OR for history of angina 0.84), lower heart rate at admission (weighted mean difference −4.02 beats/min), ST segment elevation on admission ECG (OR 3.35), AV conduction block before PVF (OR 2.02) and lower serum potassium at admission (weighted mean difference −0.27meq/L). PVF was not associated infarction site, history of myocardial infarction or hypertension.
Conclusions Patients who developed a validated PVF presented with characteristics comparable to those of patients with early hospital admission. This review provides no evidence for risk factors for PVF other than ST-elevation and time. To find new risk factors, studies should compare validated PVF patients with non-PVF patients who have no signs of heart failure and comparable time delay between onset of symptoms and medical attendance.