Abstract 677: Relationship Between Fatty Acids Level in Blood and Carotid Atherosclerosis in Patients with Coronary Artery Disease in Relation to Lipid Profile
Objective. The aim of the study was to assess changes of circulating fatty acids (FA) in relation to components of lipid profile and carotid atherosclerosis in patients with coronary artery disease (CAD).
Methods. Subjects were 58 patients, 29 males and 29 females, 54 – 69 years of age and 8 controls. Carotid intima-media thickness (IMT) were measured by duplex ultrasonography. Circulating FA, saturated FA (SFA) and unsaturated FA (UFA) (monounsaturated (MUFA) and polyunsaturated (PUFA)) in a drop of blood from a fingertip were assessed by capillary gas chromatography. The lipid profile including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides was assessed by conventional method.
Results. Palmitic and stearic (SFA); oleic (MUFA), linoleic and arachidonic (omega-6 PUFA); eicosapentaenoic (EPA), docosahexaenoic (DHA) and α-linolenic acids (omega-3 PUFA) were identified. In patients with carotid atherosclerosis, in comparison with control group, following changes were found: increased content of SFA (48.4±1.8% and 37.3± 2.9% respectively, p<0.01) including palmitic acid (35.0±1.7% and 23.9±0.6%, p<0.01) and decreased content of UFA (51.1±1.7% and 61.3±2.3% respectively, p<0.01), in particular omega-3 polyunsaturated EPA (2.6±0.76% and 4.95±1.3%, p<0.05) and DHA (1.6±0.5% and 4.6±1.6%, p<0.01). The amounts of stearic, oleic and linoleic acids did not differ between groups statistically. Some of the FA showed correlations with the lipid profile components: UFA and PUFA, particularly docosahexaenoic acids with HDL-C (r=+0.27, p<0.05; r=+0.28, p<0.05 and r=+0.23, p<0.05 respectively); eicosapentaenoic acid with total cholesterol level (r=−0.23, p<0.05). The mean IMT (1.3±0.04 mm) was correlated with SFA(r=+0.41, p<0.01) in particular with palmitic acid (r=+0.38, p<0.01). PUFA (r=−0.46, p<0.05), especially EPA(r=−0.26, p<0.05) and DHA (r=−0.25, p<0.05) were inversely related to IMT.
Conclusions. Patients with CAD are characterized by increased level of SFA and decreased level of UFA. There is an association between carotid atherosclerosis with SFA in patients with CAD.