Abstract 673: Relationship Between Plasma Adiponectin Levels and Composition of Sub-Clinical Plaque in Proximal Left Anterior Descending Coronary Artery: Intravascular Ultrasound Radio Frequency Data Analysis
Adiponectin, an adipocyte-derived antiatherogenic cytokine, has an insulin-sensitizing effect and lower plasma levels have been reported in patients with coronary heart disease. However, there has been no data demonstrating direct relationship between plasma adiponectin level and coronary plaque composition in vivo. Accordingly, we analyzed non-culprit plaque (<50% diameter stenosis) in proximal left anterior descending coronary artery (LAD) with intravascular ultrasound (IVUS) in 17 stable angina patients who underwent culprit lesion stenting. Plaque components were characterized into four categories based on the radio frequency (RF) data and percent area of each category was determined using IVUS-Virtual HistologyTM software: necrotic core (3 to 27%); fibrous (55 to 84%); fibro-fatty (5 to 28%), and dense calcium (1 to 13%). Mean plasma adiponectin level was 6.9±3.8μg/mL, ranged from 1.9 to 17.7μg/mL. There was a significant inverse relationship between plasma adiponectin level and necrotic core area (r=−0.55, p=0.023). Multivariate analysis revealed that adiponectin was an independent determinant for necrotic core area (p<0.05).
Conclusions: Lower plasma adiponectin levels were related to lipid accumulation within the plaque. Thus, even after culprit lesion stenting, those with hypoadiponectinemia may have possible future risk of acute coronary event relating to untreated sub-clinical lipid-rich plaque in proximal LAD.