Letter Regarding Article by Burke et al, “Role of SCN5A Y1102 Polymorphism in Sudden Cardiac Death in Blacks”
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To the Editor:
We would like to comment the article by Burke et al,1 who reported in a postmortem study a genetic association of the SCN5A Y1102 allele (or Y1103, for the long-splice variant) and patients with sudden cardiac death in the black population (107 noncardiac control samples, 117 with organic heart disease, 40 with cardiac hypertrophy, and 25 with cardiac arrhythmias). Because of the presence of clearly differing allele frequencies, it was concluded that the Y1102 allele might represent a marker for sudden cardiac …