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New Drugs and Technologies

Endovascular Repair of Abdominal and Thoracic Aortic Aneurysms

Barry T. Katzen, Michael D. Dake, Alexandra A. MacLean, David S. Wang
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https://doi.org/10.1161/CIRCULATIONAHA.105.541284
Circulation. 2005;112:1663-1675
Originally published September 12, 2005
Barry T. Katzen
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Michael D. Dake
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Alexandra A. MacLean
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David S. Wang
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    • Endovascular Repair of Abdominal Aortic Aneurysms
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Aortic aneurysms remain a challenging problem for patients and physicians. There have been major advances in the treatment of large-vessel aneurysms during the past 10 years. The surgical armamentarium used to treat these aneurysms now includes an endovascular approach that allows the insertion of a graft to exclude the aneurysm sac from blood flow. The endovascular repair of abdominal and thoracic aortic aneurysms has become a viable alternative to open repair and is often the approach of choice for high-risk patients. In this review, we examine the endovascular treatment of abdominal and thoracic aortic aneurysms.

Endovascular Repair of Abdominal Aortic Aneurysms

Abdominal aortic aneurysms (AAAs) are a formidable diagnosis for patients. This is a life-threatening condition that mandates consideration of repair. A ruptured AAA has a mortality rate approaching 90%; however, when an AAA is repaired electively, the mortality drops to less than 5%.1–3 There is, therefore, a clear advantage to treating these aneurysms before they rupture. Because this disease affects 4% to 7% of adults over the age of 65 years, with a far greater prevalence in males than females, clinicians will encounter this problem more frequently as the population ages.4

AAAs usually develop in patients with a history of arteriosclerosis or smoking. Patients present for repair when it is discovered that there is a dilation of their abdominal aorta to a diameter 1.5 times normal. The result is a weakened aortic wall that is at increased risk of rupture. The pathogenesis of this aortic wall change likely involves enzymes responsible for elastin and collagen breakdown.5 Recent research has focused on the role of metalloproteinase-9 (MMP-9). Aneurysm presence and size have been correlated with MMP-9 levels. Other investigators are looking into the inflammatory and autoimmune mechanisms involved in aneurysmal disease.6 Another area of research is in the molecular genetics of AAAs, because these aneurysms have a well-recognized familial nature. There is also an interest in the analysis of aortic wall stress distribution from a biomechanical approach. Ongoing studies have found that peak wall stress can predict those patients who will experience AAA rupture.7,8

Patients with symptomatic aneurysms should be offered repair, after careful consideration of comorbidities, even if the aneurysm is not of usual elective operative size. For patients with asymptomatic AAAs, there are guidelines to help plan further surveillance or operative repair. The size of the aneurysm is one factor, and the operative approach is another. In the past, the fitness of patients for a transabdominal or retroperitoneal operation was of paramount concern. High-risk patients faced the choice of a morbid operation with a not insignificant mortality rate or the risk of rupture. The treatment option for this population was not satisfactory, and the development of a lower-risk operation was a necessity to adequately treat this population.

Over the past 15 years, the management of AAAs has changed dramatically because of the development of the technique of endovascular aneurysm repair (EVAR; Figures 1 and 2⇓). Patients and physicians have embraced EVAR as the method of choice to treat high-risk patients with AAAs. EVAR has great appeal for this older population because it leads to faster recovery with fewer systemic complications than open repair.9–14

Figure1
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Figure 1. 3D rendering of 6-cm AAA.

Figure2
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Figure 2. 3D rendering of AAA 1 year after therapy with the trivascular stent graft (treated [or evaluated] under a phase I investigational device exemption clinical trial); note shrinkage of sac.

Parodi et al15 reported the first endovascular repair of an AAA in a human in 1991 using a graft fashioned from prosthetic vascular grafts and expandable stents. Current estimates are that more than 20 000 EVAR procedures take place each year in the United States, which represents ≈36% of all AAA repairs. The estimate is that >12% of all procedures in Europe are with EVAR, and expected annual growth is ≈15% at this time (Medtronic Marketing Department, personal communication, 2004). EVAR is the method of choice in high-risk older patients because of its minimal incisions, shorter operating time, and reduced blood loss.

Three EVAR devices are available commercially in the United States at this time, and several more are under evaluation in clinical trials. The Food and Drug Administration (FDA), well aware of the many confounding variables in an EVAR-to-surgery comparison, permitted the use of concurrent surgical controls. The large deposit of multicenter, prospectively collected data on the European EVAR experience also provides a great source for analyses: the EUROSTAR (EUROpean collaborators on Stent-graft Techniques for abdominal aortic Aneurysm Repair) Registry (4392 patients, 1996 to 2002).17–20

In the present review, we will address EVAR indications, contraindications, devices, outcomes, complications, endograft surveillance, and future directions. This is an exciting time for the management of AAAs, because there are many more options for high-risk patients. The field is rapidly evolving, and patients expect to be informed of the current technology.

Indications for AAA Treatment

Most asymptomatic AAAs are discovered serendipitously, often on imaging examinations for other complaints. Increasing evidence indicates that there is value to screening patients for AAAs, and it is likely that screening will be approved in the near future.21 Once the diagnosis of AAA is made, 2 critical questions need to be answered: when to intervene and how to intervene. The availability of EVAR has made these decisions somewhat more complex while adding a significant treatment option.

Recent studies have questioned whether aneurysms smaller than 5 cm should be treated.22 However, in general, the clinical recommendation remains to offer treatment for aneurysms between 5 and 5.5 cm, depending on the results of clinical trials.23 An exception to this guideline is that intervention should be offered despite the size of the aneurysm if symptoms develop or the aneurysm increases in size by 1 cm per year.24 In addition, if the patient is a woman with smaller native vessels, the relative size that represents aneurysmal disease may be less than the conventional 5 to 5.5 cm range.

Clinical and Anatomic Selection Factors

Patient selection has emerged as the most important factor related to successful EVAR. The assessment begins with consideration of the body habitus and sex of the patient; small body size and female sex have been associated with a higher risk of procedure abortion.25,26 In addition, the comorbidities of the patients must be assessed, with careful attention to cardiac, pulmonary, and renal conditions. In general, open surgical repair is advocated for younger, lower-risk patients, and EVAR is preferred for older, higher-risk patients. Open surgical repair of AAA has proven long-term durability; EVAR follow-up is now at 10 years. The use of risk stratification to analyze outcomes clearly indicates that survival for those at low to minimal risk is excellent over 10 years; those at highest risk succumb to cardiac disease or cancer, and for those patients, survival is poorest.27 EVAR has shown a reduction in 30-day mortality relative to that achieved with open repair (1.2% versus 4.6%). Further study is required to determine whether there is a long-term survival advantage. Risk stratification determines survival in general and shows that both open surgery and EVAR decrease the risk of death from AAA rupture.28

The characteristics of the aneurysm must be matched to the most suitable device; this has a direct impact on outcomes and the complication profile of the procedure. The aneurysm is evaluated from a 3D reconstruction CT scan or aortography with a calibrated catheter. There are at least 4 important features that must be assessed before one determines a patient’s eligibility for EVAR, and this analysis leads to a list of contraindications29 (Table 1). Experienced interventionalists can deal with some of these challenges, but morphological features of the aneurysm and access vessels may preclude EVAR.

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TABLE 1. Evaluation for EVAR

Currently, we use EVAR primarily to treat patients at high surgical risk. We are confident that EVAR protects patients from aneurysm rupture, but we cannot yet extend the offer of EVAR to young, healthy patients, because we do not have data on long-term durability to support this practice.

Devices

Endografts have developed from simple tube grafts suitable for a small subset of aneurysms to complex bifurcated grafts with a range of sizing and extensions that can be used to treat the morphological challenges of aneurysmal disease. The language used to describe the devices has also evolved over time.

There are 2 types of device bodies: unibody and modular. The former comes in 1 piece, and although easy to deploy, it requires contralateral occlusion and bypass grafting. Modular devices are composed of more than 1 piece, and the components are deployed through both groins. There is greater flexibility associated with the modular devices, and they dominate the market. The endograft fabric is either a woven polyester or PTFE (polytetrafluoroethylene). The difference between these is the degree of porosity (PTFE > woven polyester), and some believe this affects the rate of type IV endoleaks.

The key features of endovascular repair of AAAs that determine procedural success and long-term outcomes are proximal and distal fixation and sealing. Various device modifications and designs address this need; there are now 3 FDA-approved endografts and several others in various stages of development (Table 2). Early devices were secured proximally and distally with the aid of expandable stents. Now, most of the devices use a metal skeleton throughout the graft that is made from stainless steel, nitinol, or Elgiloy. Attachment is facilitated by the use of hooks or radial force.

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TABLE 2. Endograft Devices

Once the graft is inserted through the sheath, it can be deployed by a self-expanding mechanism or balloon expansion. Some grafts attach superior to the renal arteries (suprarenal attachment), whereas most of the devices require at least 15 mm of proximal neck to achieve fixation and sealing in the infrarenal position. The grafts also differ in their “profile” or the size of the delivery system. Low-profile devices permit access through smaller arteries.

The importance of choosing the appropriate device to fit the characteristics of the aneurysm cannot be overemphasized. With a short proximal neck, the suprarenal Talent device proves useful, and when small access arteries are encountered (especially in females), the low-profile Excluder endograft is appealing. The Lifepath device has been used with some success in the difficult angulated neck.

Outcomes

Table 3 describes the published literature from large device-specific series.9,10,12–14,30–32 Some of the series compare the EVAR data with that obtained from open surgical repair. Recently, a prospective, randomized trial of EVAR and open repair demonstrated a two thirds reduction in early mortality with EVAR.33 All studies have shown excellent rupture-free survival and significant reduction in blood loss, cardiovascular events, and intensive care unit stay. High-volume institutions with experience using multiple types of endografts are able to optimize the matching of the device to the characteristics of the aneurysm.

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TABLE 3. EVAR Outcomes

Complications

Most of the complications associated with EVAR are minor and can be watched carefully or treated easily with additional interventional procedures. Some complications occur during or soon after the procedure, whereas others are only noticed during graft surveillance (Table 4).34 A study by Ohki et al35 analyzed complication and death rates within 30 days of EVAR and found the major complication and death rates were 17.6% and 8.5%, respectively. This remains an active and important area of EVAR research, and standards have been developed to facilitate reporting of endovascular abdominal aortic repair complications.36

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TABLE 4. EVAR Complications

Endoleaks can have substantial clinical significance because of an increased risk of becoming symptomatic or leading to aneurysm rupture. Endoleak describes the continuation of blood flow into the extragraft portion of the aneurysm; this flow increases the size of the aneurysmal sac.37 Endoleaks occur in either the acute setting during graft implantation or during the postoperative surveillance period. The majority of procedural endoleaks will disappear without intervention.

Endoleaks are either graft-related or nongraft-related, and a classification system has been developed (Table 5).38 Type I endoleaks occur when the attachment is not complete, either proximally or distally; blood is able to flow into the aneurysmal sac and is not completely occluded by endograft attachment to the arterial wall. Type II endoleaks result from continued back flow from aortic branches such as the inferior mesenteric artery and lumbar arteries. This flow occurs retrograde into the aneurysmal sac around the endograft. Type III endoleaks are caused by defects in the endograft structure that lead to leakage of blood flow from inside the endograft to the aneurysmal sac. Finally, type IV endoleaks are noted early after endograft placement and resolve when the fabric porosity is decreased by clotted blood. Because endovascular repair uses a relatively new technology, graft surveillance for complications such as endoleaks is essential. Endoleaks are diagnosed by a variety of techniques: arteriography, pressure monitoring during or after the procedure, CT scan, and duplex scanning. The preferred method of detecting endoleaks is by CT scanning, An analysis of 2463 patients from the EUROSTAR registry revealed that 171 had an endoleak by the time of their first-month postoperative evaluation, and 317 patients developed one at a later date.39 Of these, 7.8% had a type II endoleak, and 12% had a type I, type III, or combination of endoleaks.

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TABLE 5. Classification of Endoleaks

There are many different ways to treat endoleaks, including coil embolization, placement of stent-graft cuffs and extensions, laparoscopic ligation of inferior mesenteric and lumbar arteries, open surgical repair, and EVAR redo procedures. Type I and III endoleaks require fairly urgent intervention, because blood flow and sac pressure will continue to increase and lead to rupture. Type IV endoleaks usually resolve on their own.

The management of type II endoleaks is more controversial, because some of them will thrombose on their own, whereas others will lead to sac enlargement. There are 2 critical questions that must be addressed at this juncture: (1) Should an intervention be entertained, and (2) when should the intervention be performed?40 One approach is to monitor the patient with a postprocedure 6-month CT scan, and if the aneurysm has increased in size, then a plan for intervention is formulated. There are at least 3 approaches to manage type II endoleaks: transarterial, translumbar embolization, and laparoscopic ligation.41 Another approach to eliminate endoleaks is to perform preoperative embolization of feeding arteries. A study by Bonvini et al42 analyzed 23 consecutive patients who underwent preoperative embolization to reduce type II endoleaks. They monitored the patients for a mean of 17 months and found 1 type II endoleak (4.5%). During a consensus conference in 2000, 23 of 26 international leaders in EVAR disagreed with the preoperative approach to endoleaks.38

Surveillance

Endograft surveillance is important to document normal and abnormal morphological changes in the repair and the involved vessels. This process is vital for the detection of endoleaks, increased aneurysm diameter, and possible device migration.43 The study by Corriere et al43 showed that 24% of the patients had an endoleak detected during surveillance that averaged 19 months. In that study, 3 endoleaks were detected 2 years after repair, with 1 at 7 years. Other findings, including perigraft air, accompanied by leukocytosis and fever, can be detected after repair and have been shown to be nonspecific and not indicative of graft infection.44

The recommended surveillance routine is for a CT scan at 1, 6, and 12 months and annually thereafter. If an endoleak is detected, the frequency of the scans increases to every 6 months until resolution of the endoleak is detected. Investigators have compared duplex ultrasound with CT scan for surveillance and found that CT scan is superior for endoleak detection.45 MRI can also be used for graft surveillance, especially in older patients with decreased renal function.46 A recent development for endograft surveillance is the monitoring of sac pressure within treated aneurysms through an implanted sensor device.47,48 Trials with this implanted sensor are currently being conducted.

The use of EVAR technology has led to a greater understanding of the basic science of aneurysmal disease. For example, Curci and Thompson6 have been studying the relationship between the secretion of matrix metalloproteinases (MMPs) and AAAs. They have measured increased levels in the aneurysmal rather than the normal arterial wall. This finding may lead to a simple test for increased aneurysm sac growth after endograft repair.49 Advances in the basic science of aneurysm disease are helping us better manage this disease.

Future Directions

EVAR has clear benefits, especially in high-risk patients. After long-term durability studies have been completed, we will have a better idea of the role of EVAR in young, healthy patients. The future of EVAR is exciting, with many new developments on the horizon. The next generation of endografts will have smaller delivery systems that will permit the application of this technology to a broader group of patients. There are endograft designs in development that will allow us to better treat aneurysms with short proximal necks and tortuous iliac arteries. The results of ongoing clinical trials will help elucidate the role of branched endografts that facilitate treatment of suprarenal aneurysms. A new implantable sac pressure–monitoring device is being studied, and the utility of this device in the surveillance of the endovascular repair may help decrease the frequency of follow-up CT scans. The EVAR story is still being written. This technology is helpful to a segment of the population of patients with AAAs, and more study will only broaden its application.

Endovascular Repair of Thoracic Aortic Aneurysms

Aortic aneurysms, both thoracic and abdominal, generally occur in the elderly and have thus been increasing in incidence as the population ages and diagnostic capabilities advance.50 With an incidence of 6 to 10 per 100 000 person-years, thoracic aortic aneurysms (TAAs) are less common than AAAs but remain life-threatening.50,51 The natural history of TAAs is one of progressive expansion and weakening of the aortic wall, leading to eventual rupture.52–54 With an associated mortality rate of 94%, TAA rupture is usually a fatal event.51,55 The 5-year survival rate of unoperated TAA patients approximates 13%, whereas 70% to 79% of those who undergo elective surgical intervention are alive at 5 years.56–58 The risk of rupture mandates consideration for surgical treatment in all patients who are suitable candidates for operation. Specific indications for operative repair are listed in Table 6. The use of endovascular stent grafts for repair of TAAs is emerging as a promising, less invasive therapeutic alternative to conventional surgical treatment.

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TABLE 6. Indications for TAA Repair

Endovascular treatment of aortic aneurysms is achieved by transluminal placement of 1 or more stent-graft devices across the longitudinal extent of the lesion (Figure 3). The prosthesis bridges the aneurysmal sac to exclude it from high-pressure aortic blood flow, thereby allowing for sac thrombosis around the endograft and possible remodeling of the aortic wall. Although the advent and ensuing rapid evolution of endovascular aortic repair occurred initially in the abdominal aorta, efforts to adapt this technology for the thoracic aorta are ongoing. As is the case for AAA, a less invasive approach to TAA repair is highly desirable, because the patient population tends to be elderly and harbors multiple comorbidities.54,58,59 Continued development of endovascular therapy for thoracic aneurysms, however, is likely to provide greater benefits in patient outcomes than those observed with AAAs. Conventional surgical treatment of TAA is physiologically more demanding and carries a greater operative risk. It mandates open thoracotomy, aortic cross-clamping, resection of the aneurysm, and replacement with a prosthetic graft, and it often requires cardiopulmonary bypass.60 Despite advances in operative technique, intraoperative monitoring, and postoperative care, the mortality and morbidity of surgery remain substantial and less favorable than outcomes for open AAA repair. Mortality for TAA surgical repair ranges from 5% to 20% in elective cases and to 50% in emergent situations.58,61–63 Major complications associated with surgical TAA treatment include renal and pulmonary failure, visceral and cardiac ischemia, stroke, and paraplegia. Paraplegia is a particularly devastating complication nearly unique to the surgical treatment of thoracic aneurysms, occurring in 5% to 25% of cases versus <1% for AAAs.56,58,64–67 For these reasons, a significant population of TAA patients are not candidates for open repair and have been without a treatment option until recently.

Figure3
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Figure 3. Stent-graft repair of thoracic aortic pseudoaneurysm. A, Thoracic aortogram illustrates large aneurysm in a 58-year-old man who had surgery 22 years earlier to repair a traumatic aortic injury from a motor vehicle accident. B, Aortogram after stent-graft placement shows widely patent device without evidence of contrast media endoleak into the aneurysm sac.

Endovascular aneurysm repair of the thoracic aorta is currently focused on the descending portion, defined as being distal to the left subclavian artery. Approximately half of TAAs are located in the descending thoracic aorta.51,59 Anatomically, this aortic segment provides a substrate more amenable for endovascular stent-graft repair given its avoidance of the great vessels proximally and major visceral branches and aortic bifurcation distally. Despite these anatomic advantages and the ability to draw from early experiences with endovascular AAA repair, the development of stent grafting in the thoracic aorta has progressed more slowly than that of its infrarenal counterpart. The thoracic aorta poses several unique challenges that have impeded simple adaptation of endovascular devices and techniques developed for the abdominal aorta.68 First, the hemodynamic forces of the thoracic aorta are significantly more aggressive and place greater mechanical demands on thoracic endografts. The potential for device migration, kinking, and late structural failures are important concerns. Second, greater flexibility is required of thoracic devices to conform to the natural curvature of the proximal descending aorta and to lesions with tortuous morphology. Third, because larger devices are necessary to accommodate the diameter of the thoracic aorta, arterial access is more problematic. This is an important concern given the greater proportion of TAA patients, relative to AAA patients, who are women, in whom access vessels tend to be smaller. Fourth, as with conventional open TAA repair, paraplegia remains a potential complication in the endovascular approach despite the absence of aortic cross-clamping.69,70 Lastly, the extent of TAAs can often extend beyond the boundaries of the descending thoracic aorta and involve more proximal or distal aorta than desired. Management of the left subclavian artery, in particular, has gained considerable attention.71–73

With these challenges in mind, significant progress has been achieved since the first stent graft was deployed for TAA exclusion in 1992.69,74 Although the development of thoracic stent-graft technology remains in its adolescent stages, the cumulative clinical experience with an estimated 5000 implants worldwide has yielded short- to mid-term data that demonstrate promising results. This review will provide an update on the current state of endovascular management of aneurysms in the descending thoracic aorta.

Devices

Early clinical experiences with stent grafting of the thoracic aorta were based on the use of first-generation, homemade devices that were rigid and required large delivery systems (24F to 27F).74,75 Fortunately, several commercial manufacturers of abdominal endografts have created derivatives for the thoracic aorta with dramatic improvements over homemade devices. To date, none have been approved for use in the United States, but 3 are undergoing clinical trials for FDA approval (Figure 4; Table 7): TAG (W.L. Gore and Associates, Inc), Talent (Medtronic, Inc), and TX2 (Cook, Inc).

Figure4
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Figure 4. Current thoracic stent grafts undergoing US clinical trials. Left, TAG device manufactured by WL Gore & Associates, Inc is composed of PTFE graft material and nitinol stent forms. Middle, Talent thoracic graft from Medtronic, Inc is fabricated from nitinol and polyester graft. Right, TX2 Zenith device created by Cook, Inc is a 2-component endograft with stainless steel stent bodies and polyester graft material.

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TABLE 7. Devices Undergoing FDA Review for TAA Repair

Although each device has unique features, all 3 employ the same basic structural design. The endoprostheses are composed of a stent (nitinol or stainless steel) covered with fabric (polyester or PTFE). The modular design of the TX2 system renders it less flexible than the TAG but more so than the Talent. The TAG device uses a delivery system that is specifically designed to limit distal migration. The design of the proximal and distal ends varies, and some of the stents are uncovered proximally and distally (TX2), whereas others have an uncovered proximal end (Talent). In addition, the TX2 stent uses barbs to facilitate fixation proximally and distally. Ultimately, each device has its advantages and disadvantages.

Requirements for Endovascular Repair

The evaluation of a patient for repair of their TAA considers their overall risk profile, evidence of rapid enlargement of the aneurysm, diameter ≥6 cm, or presence of symptoms. The suitability of the patient for endovascular repair is based on both clinical and anatomic considerations. Clinical parameters indicating a preference for the endovascular approach over the traditional approach remain to be defined but should be based on comparison of respective risk-benefit ratios. Although data from long-term follow-up studies and randomized, controlled trials are pending, endovascular stent grafting is currently reserved for high-surgical-risk and nonoperative patients who have suitable anatomic features.

General consensus has been established for anatomic prerequisites for endovascular repair (Table 8). Thorough preprocedural imaging is essential to fully characterize the lesion and access route. Detailed imaging evaluation can be obtained with spiral CT or MRI; however, without the availability of high resolution 3D renderings of the aorta, catheter-based angiography remains the “gold standard.” Measurements from imaging data are used to select the appropriate device diameter and length.

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TABLE 8. Anatomic Requirements for Endovascular Repair of TAA

Determination of aneurysm location in relation to the left subclavian artery and celiac axis is of upmost importance. Successful TAA exclusion requires normal segments of native aorta at both ends of the lesion (the so-called landing zone or neck) of at least 15 to 25 mm to ensure adequate endoprosthesis–aortic wall contact and formation of a tight circumferential seal. Landing zones that are markedly angled or conical or that contain thrombus can result in poor fixation. Devices are oversized by 10% to 20% in diameter to provide sufficient radial force for adequate fixation.

The vascular access route for device introduction and delivery to the pathological target must be of sufficient size and of suitable morphology. Stent grafts are most commonly introduced through the femoral artery. Small-diameter, tortuous, and excessively calcified iliac arteries may preclude such access, requiring more proximal retroperitoneal exposure and direct cannulation of or creation of a graft conduit to the common iliac or abdominal aorta. Additionally, severe stenosis and tortuosity of the abdominal and thoracic aorta distal to the target are contraindications for endovascular repair.

In spite of the use of these criteria, treatment failures can occur, but the specific contributing factors and frequencies are currently unknown, particularly over the long-term. Thus, follow-up surveillance with serial CT scans at 1, 6, and 12 months and annually thereafter is recommended to monitor changes in aneurysm morphology, identify device failures, and detect endoleaks.

Clinical Experience

The literature on thoracic stent grafting consists mostly of small to medium-sized case series with short- to medium-term follow-up (Table 9). Nevertheless, these studies illustrate a consensual pattern of outcomes when viewed in aggregate. Overall, successful device deployment is achieved in 85% to 100% of cases, and periprocedural mortality ranges from 0% to 14%, falling within or below elective surgery mortality rates of 5% to 20%.68,75–90 As expected, outcomes have improved over time with accumulated technical expertise, use of commercially manufactured devices, and improved patient selection criteria. The recently published collective experiences of the EUROSTAR and United Kingdom Thoracic Endograft registries, the largest series to date (n=249), demonstrate successful deployment in 87% of cases, 30-day mortality of 5% for elective cases, and paraplegia and endoleak rates of 4%.90 FDA phase II trial data from exclusive deployment of the Gore TAG endograft in 142 TAA patients reveal similar results: technical success in 98%, 30-day mortality of 1.5%, paraplegia in 3.5%, and endoleak in 8.8%.89

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TABLE 9. Summary Data on Studies of Endovascular Repair of TAA

These results cannot be directly compared with the outcomes of contemporary surgical studies. The majority of TAA patients who were repaired by the endovascular approach in these studies were older and sicker, having been deemed either high risk or not suitable for open surgical repair. For example, 52% of patients in the combined EUROSTAR and United Kingdom registries were preoperatively classified as ASA 3 or above (American Society of Anesthesiologists’ physical status classification that predicts procedural risk: 1 to 2 indicates low risk; 3, intermediate risk; 4 to 5, high risk; and 6, organ donor).90 In light of these patient substrate differences, endovascular TAA repair will likely play a substantial role in the management of high-risk patients. Furthermore, the applications of this less invasive therapeutic modality may broaden if endograft studies with lower-risk surgical candidates result in favorable mortality and morbidity gains, particularly as devices and techniques continue to evolve.

True comparisons between conventional therapy and the endovascular alternative can only be achieved after the completion of prospective, randomized, controlled trials. Although such trials are under way, a few studies have compared endovascular treatment with anatomically similar open-surgery historic controls. As part of the phase II Gore Excluder study, 19 TAA patients who were candidates for open repair received stent-graft therapy and were compared with a nonrandomized cohort of 10 patients who had undergone open repair before the availability of thoracic stent grafts.81 All aneurysms met the same inclusion/exclusion criteria for anatomic involvement. One-year survival was 89.5% in the endovascular group and 70% in the operative group. As expected, mean hospital stay (6.2 versus 16.3 days) and length of intervention (155 versus 256 minutes) were significantly less among those treated endovascularly. In a similar study, Ehrlich and colleagues found decreased 30-day mortality (10% versus 31%), mean hospital stay (6 versus 10 days), and mean intervention time (150 versus 325 minutes) in the endovascular group; the paraplegia rate was also decreased (0% versus 12%).76

Complications

With the avoidance of aortic cross-clamping and prolonged iatrogenic hypotension, endovascular TAA repair was expected to result in lower incidences of paraplegia relative to conventional treatment. Indeed, this has held true, with paraplegia rates generally ranging from 0% to 5% in endovascular studies,68,75–90 whereas paraplegia occurs in 5% to 25% of open repair cases.56,58,64,65 Although low, these rates remain significant, especially because it is impossible to reimplant intercostal arteries in this setting. Some evidence suggests that the occurrence of paraplegia is associated with concomitant or prior surgical AAA repair and increased exclusion length because of the absence of lumbars and hypogastric collateral circulation.79,91 Adjunctive measures to further reduce spinal cord ischemic complication rates in endovascular TAA repair are being investigated.92

Endoleaks are the most prevalent of TAA stent-graft treatment complications. However, their observed frequency is substantially less than that reported for AAA endograft repair.93 Interestingly, the distribution of endoleak types also differs. TAA endoleaks occur more commonly at the proximal or distal attachment sites (type I endoleak), whereas the majority of AAA endoleaks are type II.94 It is generally accepted that type I endoleaks are more serious and require expeditious intervention because they represent direct communications between the aneurysm sac and aortic blood flow.95 Treatment options include transcatheter coil or glue embolization, balloon angioplasty, placement of endovascular graft extensions, and open repair.96,97

Despite the hostile hemodynamic conditions of the thoracic aorta, the anticipated complications of device migration and kinking have occurred infrequently and have been observed primarily with homemade devices and those with unsupported mid-graft segments.70 For both homemade and commercial endografts, however, questions about device durability and stability over the long term remain unanswered.

Future Directions

The cumulative worldwide experience with endovascular repair of thoracic aneurysms has highlighted not only its potential as an advance in treatment but also its limitations. Efforts are under way to expand the applicability of endovascular stent-graft technology in the thoracic aorta, challenging current anatomic constraints and clinical indications. A variety of exciting strategies are being explored and deserve mention.

Although current anatomic criteria limit thoracic stent-graft exclusion to lesions located at least 15 to 25 mm away from the origin of the left subclavian artery and celiac trunk, it is common for descending TAAs to be located within the proximal or distal neck length necessary for adequate fixation. At the proximal end, the landing zone can be extended by prophylactic left subclavian to left carotid artery transposition or bypass graft placement.69 Alternatively, the uncovered proximal portion of the Talent endograft can be placed across the left subclavian origin to achieve fixation without blocking flow. However, because case reports of inadvertent coverage of the left subclavian artery origin found no resulting complications,98 subsequent studies determined that such maneuvers may not be necessary as long as there is no obstruction of the right vertebral or carotid artery and the left internal mammary artery is not used as a coronary bypass conduit.71–73 Complications such as left arm ischemia were found to be rare, possibly owing to collateral blood supply via retrograde left vertebral flow. This is commonly referred to as the “subclavian steal” phenomenon. Most centers now intentionally cover the left subclavian origin when necessary and reserve secondary revascularization procedures for when related symptoms develop.69

For even more proximal thoracic aneurysms involving the aortic arch, branched and fenestrated stent grafts are being developed to accommodate perfusion through the great vessels.99,100 Although feasibility has been demonstrated, it is already apparent that the required implantation techniques would have to be highly complex and demand considerable technical expertise. Some centers have thus been investigating techniques to create fenestrations intraoperatively after device deployment and coverage of critical branches.101

In contrast, there are no easy management strategies to deal with a short distal neck. In this setting as well, fenestrated and branched grafts have been used in isolated cases, but the overall experience is very limited. Intentional coverage of the celiac artery is not recommended given the risk of hepatic and visceral ischemia. Although a normal superior mesenteric artery may provide collateral flow, no methods exist to predetermine whether such collateral supply would be sufficient. Furthermore, the celiac trunk may serve as a prominent source of retrograde endoleak if covered without adjunctive transcatheter occlusion. In distal aneurysms that involve both the descending thoracic and abdominal aorta, combined open AAA repair and endovascular TAA exclusion is a novel treatment approach under investigation.

Stent grafts are also being used to treat patients with diffuse aneurysmal disease involving the entire thoracic aorta. In such patients, the traditional surgical treatment is a 2-staged procedure named the “elephant trunk technique.”102 In the first stage, the ascending aorta and aortic arch are repaired via a median sternotomy, and an extra-long graft is used for reconstruction, which leaves the excess portion of the graft, the elephant trunk, dangling within the lumen of the remaining diseased aorta. In the second stage, the lesion in the descending aorta is repaired via a left thoracotomy, and the graft replacement is connected to the elephant trunk proximally. To bypass the need for thoracotomy, a few centers have successfully deployed thoracic stent grafts into the elephant trunk extension, altogether replacing the second stage of the traditional elephant trunk procedure.103

Following closely on the heels of early clinical experiences with stent grafting for TAA repair, experimental application of this less invasive approach has been extended to a growing number of other pathologies of the thoracic aorta. Most noteworthy among these are aortic dissection,104 traumatic aortic injury,105 penetrating atherosclerotic ulcer,106 and aortic rupture.107 Some investigators believe that thoracic stent-graft technology may eventually yield the greatest impact on clinical care in the management of aortic dissections, because current treatment standards are far from optimal.

Conclusions

The emergence of endovascular stent grafting as an alternative therapy to open surgical repair of abdominal and thoracic aneurysms is an exciting advance. Although it is apparent that high-operative-risk patients will benefit from this technology, the exact role of stent grafting remains to be defined as we continue to accumulate long-term data and experience and as devices and techniques evolve. Instead of replacing conventional surgical treatment, endovascular repair will likely play a complementary role and offer a less invasive option in our treatment armamentarium. It is clear that the limitations of both approaches are distinct. Although what is considered high risk for surgery is defined by clinical parameters in terms of comorbidities and physiological reserve, contraindications for endovascular stent-graft treatment are defined by anatomical constraints. In this regard, each may fulfill the treatment gaps left by the other.

Acknowledgments

Disclosures

Dr Dake has received research grants from Cook and W.L. Gore; has served on the speakers’ bureau of Cook; and has consulted for W.L. Gore. Dr Katzen has consulted for and received educational grants from Cook, Boston Scientific, W.L. Gore, and Medtronic.

References

  1. ↵
    Ernst CB. Abdominal aortic aneurysm. N Engl J Med. 1993; 328: 1167–1172.
    OpenUrlCrossRefPubMed
  2. ↵
    Thomas PR, Stewart RD. Abdominal aortic aneurysm. Br J Surg. 1988; 75: 733–736.
    OpenUrlCrossRefPubMed
  3. ↵
    Noel AA, Gloviczki P, Cherry KJ Jr, Bower TC, Panneton JM, Mozes GI, Harmsen WS, Jenkins GD, Hallett JW Jr. Ruptured abdominal aortic aneurysms: the excessive mortality rate of conventional repair. J Vasc Surg. 2001; 34: 41–46.
    OpenUrlCrossRefPubMed
  4. ↵
    Scott RA, Wilson NM, Ashton HA, Kay DN. Influence of screening on the incidence of ruptured abdominal aortic aneurysm: 5-year results of a randomized controlled study. Br J Surg. 1995; 82: 1066–1070.
    OpenUrlCrossRefPubMed
  5. ↵
    Wassef M, Baxter BT, Chisholm RL, Dalman RL, Fillinger MF, Heinecke J, Humphrey JD, Kuivaniemi H, Parks WC, Pearce WH, Platsoucas CD, Sukhova GK, Thompson RW, Tilson MD, Zarins CK. Pathogenesis of abdominal aortic aneurysms: a multidisciplinary research program supported by the National Heart, Lung, and Blood Institute. J Vasc Surg. 2001; 34: 730–738.
    OpenUrlCrossRefPubMed
  6. ↵
    Curci JA, Thompson RW. Adaptive cellular immunity in aortic aneurysms: cause, consequence, or context? J Clin Invest. 2004; 114: 168–171.
    OpenUrlCrossRefPubMed
  7. ↵
    Fillinger MF, Marra SP, Raghavan ML, Kennedy FE. Prediction of rupture risk in abdominal aortic aneurysm during observation: wall stress versus diameter. J Vasc Surg. 2003; 37: 724–732.
    OpenUrlCrossRefPubMed
  8. ↵
    Fillinger MF, Raghavan ML, Marra SP, Cronenwett JL, Kennedy FE. In vivo analysis of mechanical wall stress and abdominal aortic aneurysm rupture risk. J Vasc Surg. 2002; 36: 589–597.
    OpenUrlCrossRefPubMed
  9. ↵
    Criado FJ, Fairman RM, Becker GJ. Talent LPS AAA stent graft: results of a pivotal clinical trial. J Vasc Surg. 2003; 37: 709–715.
    OpenUrlCrossRefPubMed
  10. ↵
    Matsumura JS, Brewster DC, Makaroun MS, Naftel DC. A multicenter controlled clinical trial of open versus endovascular treatment of abdominal aortic aneurysm. J Vasc Surg. 2003; 37: 262–271.
    OpenUrlCrossRefPubMed
  11. ↵
    Ouriel K, Clair DG, Greenberg RK, Lyden SP, O’Hara PJ, Sarac TP, Srivastava SD, Butler B, Sampram ES. Endovascular repair of abdominal aortic aneurysms: device-specific outcome. J Vasc Surg. 2003; 37: 991–998.
    OpenUrlCrossRefPubMed
  12. ↵
    Moore WS. The Guidant Ancure bifurcation endograft: five-year follow-up. Semin Vasc Surg. 2003; 16: 139–143.
    OpenUrlPubMed
  13. ↵
    Zarins CK, White RA, Moll FL, Crabtree T, Bloch DA, Hodgson KJ, Fillinger MF, Fogarty TJ. The AneuRx stent graft: four-year results and worldwide experience 2000. J Vasc Surg. 2001; 33: S135–S145.
    OpenUrlCrossRefPubMed
  14. ↵
    Greenberg RK, Chuter TA, Sternbergh WC III, Fearnot NE. Zenith AAA endovascular graft: intermediate-term results of the US multicenter trial. J Vasc Surg. 2004; 39: 1209–1218.
    OpenUrlCrossRefPubMed
  15. ↵
    Parodi JC, Palmaz JC, Barone HD. Transfemoral intraluminal graft implantation for abdominal aortic aneurysms. Ann Vasc Surg. 1991; 5: 491–499.
    OpenUrlCrossRefPubMed
  16. Deleted in proof.
  17. ↵
    Buth J. Endovascular repair of abdominal aortic aneurysms: results from the EUROSTAR registry: EUROpean collaborators on Stent-graft Techniques for abdominal aortic Aneurysm Repair. Semin Interv Cardiol. 2000; 5: 29–33.
    OpenUrlPubMed
  18. ↵
    Buth J, van Marrewijk CJ, Harris PL, Hop WC, Riambau V, Laheij RJ. Outcome of endovascular abdominal aortic aneurysm repair in patients with conditions considered unfit for an open procedure: a report on the EUROSTAR experience. J Vasc Surg. 2002; 35: 211–221.
    OpenUrlCrossRefPubMed
  19. ↵
    Harris PL, Buth J. An update on the important findings from the EUROSTAR EVAR registry. Vascular. 2004; 12: 33–38.
    OpenUrlAbstract/FREE Full Text
  20. ↵
    Harris PL, Vallabhaneni SR, Desgranges P, Becquemin JP, van Marrewijk C, Laheij RJ. Incidence and risk factors of late rupture, conversion, and death after endovascular repair of infrarenal aortic aneurysms: the EUROSTAR experience: European Collaborators on Stent/graft techniques for aortic aneurysm repair. J Vasc Surg. 2000; 32: 739–749.
    OpenUrlCrossRefPubMed
  21. ↵
    Kent KC, Zwolak RM, Jaff MR, Hollenbeck ST, Thompson RW, Schermerhorn ML, Sicard GA, Riles TS, Cronenwett JL. Screening for abdominal aortic aneurysm: a consensus statement. J Vasc Surg. 2004; 39: 267–269.
    OpenUrlCrossRefPubMed
  22. ↵
    The UK Small Aneurysm Trial Participants. Mortality results for randomised controlled trial of early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms. Lancet. 1998; 352: 1649–1655.
    OpenUrlCrossRefPubMed
  23. ↵
    Powell JT, Greenhalgh RM. Clinical practice: small abdominal aortic aneurysms. N Engl J Med. 2003; 348: 1895–1901.
    OpenUrlCrossRefPubMed
  24. ↵
    Scott RA, Tisi PV, Ashton HA, Allen DR. Abdominal aortic aneurysm rupture rates: a 7-year follow-up of the entire abdominal aortic aneurysm population detected by screening. J Vasc Surg. 1998; 28: 124–128.
    OpenUrlCrossRefPubMed
  25. ↵
    Mathison M, Becker GJ, Katzen BT, Benenati JF, Zemel G, Powell A, Kovacs ME, Lima MM. The influence of female gender on the outcome of endovascular abdominal aortic aneurysm repair. J Vasc Interv Radiol. 2001; 12: 1047–1051.
    OpenUrlPubMed
  26. ↵
    Mathison MN, Becker GJ, Katzen BT, Benenati JF, Zemel G, Powell A, Lima MM. Implications of problematic access in transluminal endografting of abdominal aortic aneurysm. J Vasc Interv Radiol. 2003; 14: 33–39.
    OpenUrlPubMed
  27. ↵
    Becker GJ, Kovacs M, Mathison MN, Katzen BT, Benenati JF, Zemel G, Powell A, Almeida JI, Alvarez J Jr, Coello AA, Ingegno MD, Kanter SR, Katzman HE, Puente OA, Reiss IM, Rua I, Gordon R, Baquero J. Risk stratification and outcomes of transluminal endografting for abdominal aortic aneurysm: 7-year experience and long-term follow-up. J Vasc Interv Radiol. 2001; 12: 1033–1046.
    OpenUrlCrossRefPubMed
  28. ↵
    Huber TS, Wang JG, Derrow AE, Dame DA, Ozaki CK, Zelenock GB, Flynn TC, Seeger JM. Experience in the United States with intact abdominal aortic aneurysm repair. J Vasc Surg. 2001; 33: 304–310.
    OpenUrlCrossRefPubMed
  29. ↵
    Ohki T, Veith FJ. Patient selection for endovascular repair of abdominal aortic aneurysms: changing the threshold for intervention. Semin Vasc Surg. 1999; 12: 226–234.
    OpenUrlPubMed
  30. ↵
    Carpenter JP, Anderson WN, Brewster DC, Kwolek C, Makaroun M, Martin J, McCann R, McKinsey J, Beebe HG. Multicenter pivotal trial results of the Lifepath System for endovascular aortic aneurysm repair. J Vasc Surg. 2004; 39: 34–43.
    OpenUrlCrossRefPubMed
  31. ↵
    Carpenter JP. Multicenter trial of the PowerLink bifurcated system for endovascular aortic aneurysm repair. J Vasc Surg. 2002; 36: 1129–1137.
    OpenUrlCrossRefPubMed
  32. ↵
    Engellau L, Albrechtsson U, Norgren L, Larsson EM. Long-term results after endovascular repair of abdominal aortic aneurysms with the Stentor and Vanguard stent-graft. Acta Radiol. 2004; 45: 275–283.
    OpenUrlCrossRefPubMed
  33. ↵
    Greenhalgh RM, Brown LC, Kwong GP, Powell JT, Thompson SG. Comparison of endovascular aneurysm repair with open repair in patients with abdominal aortic aneurysm (EVAR trial 1), 30-day operative mortality results: randomised controlled trial. Lancet. 2004; 364: 843–848.
    OpenUrlCrossRefPubMed
  34. ↵
    Elkouri S, Gloviczki P, McKusick MA, Panneton JM, Andrews J, Bower TC, Noel AA, Harmsen WS, Hoskin TL, Cherry K. Perioperative complications and early outcome after endovascular and open surgical repair of abdominal aortic aneurysms. J Vasc Surg. 2004; 39: 497–505.
    OpenUrlCrossRefPubMed
  35. ↵
    Ohki T, Veith FJ, Shaw P, Lipsitz E, Suggs WD, Wain RA, Bade M, Mehta M, Cayne N, Cynamon J, Valldares J, McKay J. Increasing incidence of midterm and long-term complications after endovascular graft repair of abdominal aortic aneurysms: a note of caution based on a 9-year experience. Ann Surg. 2001; 234: 323–334.
    OpenUrlCrossRefPubMed
  36. ↵
    Chaikof EL, Blankensteijn JD, Harris PL, White GH, Zarins CK, Bernhard VM, Matsumura JS, May J, Veith FJ, Fillinger MF, Rutherford RB, Kent KC. Reporting standards for endovascular aortic aneurysm repair. J Vasc Surg. 2002; 35: 1048–1060.
    OpenUrlCrossRefPubMed
  37. ↵
    White GH, Yu W, May J. Endoleak: a proposed new terminology to describe incomplete aneurysm exclusion by an endoluminal graft. J Endovasc Surg. 1996; 3: 124–125.
    OpenUrl
  38. ↵
    Veith FJ, Baum RA, Ohki T, Amor M, Adiseshiah M, Blankensteijn JD, Buth J, Chuter TA, Fairman RM, Gilling-Smith G, Harris PL, Hodgson KJ, Hopkinson BR, Ivancev K, Katzen BT, Lawrence-Brown M, Meier GH, Malina M, Makaroun MS, Parodi JC, Richter GM, Rubin GD, Stelter WJ, White GH, White RA, Wisselink W, Zarins CK. Nature and significance of endoleaks and endotension: summary of opinions expressed at an international conference. J Vasc Surg. 2002; 35: 1029–1035.
    OpenUrlCrossRefPubMed
  39. ↵
    van Marrewijk C, Buth J, Harris PL, Norgren L, Nevelsteen A, Wyatt MG. Significance of endoleaks after endovascular repair of abdominal aortic aneurysms: the EUROSTAR experience. J Vasc Surg. 2002; 35: 461–473.
    OpenUrlCrossRefPubMed
  40. ↵
    Maldonado TS, Gagne PJ. Controversies in the management of type II “branch” endoleaks following endovascular abdominal aortic aneurysm repair. Vasc Endovascular Surg. 2003; 37: 1–12.
    OpenUrlAbstract/FREE Full Text
  41. ↵
    Hinchliffe RJ, Singh-Ranger R, Whitaker SC, Hopkinson BR. Type II endoleak: transperitoneal sacotomy and ligation of side branch endoleaks responsible for aneurysm sac expansion. J Endovasc Ther. 2002; 9: 539–542.
    OpenUrlCrossRefPubMed
  42. ↵
    Bonvini R, Alerci M, Antonucci F, Tutta P, Wyttenbach R, Bogen M, Pelloni A, Von Segesser L, Gallino A. Preoperative embolization of collateral side branches: a valid means to reduce type II endoleaks after endovascular AAA repair. J Endovasc Ther. 2003; 10: 227–232.
    OpenUrlCrossRefPubMed
  43. ↵
    Corriere MA, Feurer ID, Becker SY, Dattilo JB, Passman MA, Guzman RJ, Naslund TC. Endoleak following endovascular abdominal aortic aneurysm repair: implications for duration of screening. Ann Surg. 2004; 239: 800–805.
    OpenUrlCrossRefPubMed
  44. ↵
    Velazquez OC, Carpenter JP, Baum RA, Barker CF, Golden M, Criado F, Pyeron A, Fairman RM. Perigraft air, fever, and leukocytosis after endovascular repair of abdominal aortic aneurysms. Am J Surg. 1999; 178: 185–189.
    OpenUrlCrossRefPubMed
  45. ↵
    Raman KG, Missig-Carroll N, Richardson T, Muluk SC, Makaroun MS. Color-flow duplex ultrasound scan versus computed tomographic scan in the surveillance of endovascular aneurysm repair. J Vasc Surg. 2003; 38: 645–651.
    OpenUrlCrossRefPubMed
  46. ↵
    Engellau L, Albrechtsson U, Hojgard S, Norgren L, Larsson EM. Costs in follow-up of endovascularly repaired abdominal aortic aneurysms: magnetic resonance imaging with MR angiography versus EUROSTAR protocols. Int Angiol. 2003; 22: 36–42.
    OpenUrlPubMed
  47. ↵
    Baum RA, Carpenter JP, Cope C, Golden MA, Velazquez OC, Neschis DG, Mitchell ME, Barker CF, Fairman RM. Aneurysm sac pressure measurements after endovascular repair of abdominal aortic aneurysms. J Vasc Surg. 2001; 33: 32–41.
    OpenUrlCrossRefPubMed
  48. ↵
    Ellozy SH, Carroccio A, Lookstein RA, Minor ME, Sheahan CM, Juta J, Cha A, Valenzuela R, Addis MD, Jacobs TS, Teodorescu VJ, Marin ML. First experience in human beings with a permanently implantable intrasac pressure transducer for monitoring endovascular repair of abdominal aortic aneurysms. J Vasc Surg. 2004; 40: 405–412.
    OpenUrlCrossRefPubMed
  49. ↵
    Sangiorgi G, D’Averio R, Mauriello A, Bondio M, Pontillo M, Castelvecchio S, Trimarchi S, Tolva V, Nano G, Rampoldi V, Spagnoli LG, Inglese L. Plasma levels of metalloproteinases-3 and -9 as markers of successful abdominal aortic aneurysm exclusion after endovascular graft treatment. Circulation. 2001; 104 (suppl I): I-288–I-295.
    OpenUrlPubMed
  50. ↵
    Clouse WD, Hallett JW Jr, Schaff HV, Gayari MM, Ilstrup DM, Melton LJ III. Improved prognosis of thoracic aortic aneurysms: a population-based study. JAMA. 1998; 280: 1926–1929.
    OpenUrlCrossRefPubMed
  51. ↵
    Bickerstaff LK, Pairolero PC, Hollier LH, Melton LJ, Van Peenen HJ, Cherry KJ, Joyce JW, Lie JT. Thoracic aortic aneurysms: a population-based study. Surgery. 1982; 92: 1103–1108.
    OpenUrlPubMed
  52. ↵
    Coady MA, Rizzo JA, Goldstein LJ, Elefteriades JA. Natural history, pathogenesis, and etiology of thoracic aortic aneurysms and dissections. Cardiol Clin. 1999; 17: 615–635.
    OpenUrlCrossRefPubMed
  53. ↵
    Crawford ES, DeNatale RW. Thoracoabdominal aortic aneurysm: observations regarding the natural course of the disease. J Vasc Surg. 1986; 3: 578–582.
    OpenUrlCrossRefPubMed
  54. ↵
    McNamara JJ, Pressler VM. Natural history of arteriosclerotic thoracic aortic aneurysms. Ann Thorac Surg. 1978; 26: 468–473.
    OpenUrlCrossRefPubMed
  55. ↵
    Johansson G, Markstrom U, Swedenborg J. Ruptured thoracic aortic aneurysms: a study of incidence and mortality rates. J Vasc Surg. 1995; 21: 985–988.
    OpenUrlCrossRefPubMed
  56. ↵
    DeBakey ME, McCollum CH, Graham JM. Surgical treatment of aneurysms of the descending thoracic aorta: long-term results in 500 patients. J Cardiovasc Surg (Torino). 1978; 19: 571–576.
    OpenUrlPubMed
  57. ↵
    Hilgenberg AD, Rainer WG, Sadler TR Jr. Aneurysm of the descending thoracic aorta: replacement with the use of a shunt or bypass. J Thorac Cardiovasc Surg. 1981; 81: 818–824.
    OpenUrlPubMed
  58. ↵
    Moreno-Cabral CE, Miller DC, Mitchell RS, Stinson EB, Oyer PE, Jamieson SW, Shumway NE. Degenerative and atherosclerotic aneurysms of the thoracic aorta: determinants of early and late surgical outcome. J Thorac Cardiovasc Surg. 1984; 88: 1020–1032.
    OpenUrlPubMed
  59. ↵
    Pressler V, McNamara JJ. Thoracic aortic aneurysm: natural history and treatment. J Thorac Cardiovasc Surg. 1980; 79: 489–498.
    OpenUrlPubMed
  60. ↵
    Fann JI. Descending thoracic and thoracoabdominal aortic aneurysms. Coron Artery Dis. 2002; 13: 93–102.
    OpenUrlCrossRefPubMed
  61. ↵
    Svensson LG, Crawford ES, Hess KR, Coselli JS, Safi HJ. Variables predictive of outcome in 832 patients undergoing repairs of the descending thoracic aorta. Chest. 1993; 104: 1248–1253.
    OpenUrlCrossRefPubMed
  62. ↵
    Borst HG, Jurmann M, Buhner B, Laas J. Risk of replacement of descending aorta with a standardized left heart bypass technique. J Thorac Cardiovasc Surg. 1994; 107: 126–132.
    OpenUrlPubMed
  63. ↵
    Pressler V, McNamara JJ. Aneurysm of the thoracic aorta: review of 260 cases. J Thorac Cardiovasc Surg. 1985; 89: 50–54.
    OpenUrlPubMed
  64. ↵
    Svensson LG, Crawford ES, Hess KR, Coselli JS, Safi HJ. Experience with 1509 patients undergoing thoracoabdominal aortic operations. J Vasc Surg. 1993; 17: 357–368.
    OpenUrlCrossRefPubMed
  65. ↵
    Livesay JJ, Cooley DA, Ventemiglia RA, Montero CG, Warrian RK, Brown DM, Duncan JM. Surgical experience in descending thoracic aneurysmectomy with and without adjuncts to avoid ischemia. Ann Thorac Surg. 1985; 39: 37–46.
    OpenUrlCrossRefPubMed
  66. ↵
    Berg P, Kaufmann D, van Marrewijk CJ, Buth J. Spinal cord ischaemia after stent-graft treatment for infra-renal abdominal aortic aneurysms: analysis of the EUROSTAR database. Eur J Vasc Endovasc Surg. 2001; 22: 342–347.
    OpenUrlCrossRefPubMed
  67. ↵
    Rosenthal D. Spinal cord ischemia after abdominal aortic operation: is it preventable? J Vasc Surg. 1999; 30: 391–397.
    OpenUrlCrossRefPubMed
  68. ↵
    Ouriel K, Greenberg RK. Endovascular treatment of thoracic aortic aneurysms. J Card Surg. 2003; 18: 455–463.
    OpenUrlCrossRefPubMed
  69. ↵
    Dake MD. Endovascular stent-graft management of thoracic aortic diseases. Eur J Radiol. 2001; 39: 42–49.
    OpenUrlCrossRefPubMed
  70. ↵
    Gravereaux EC, Faries PL, Burks JA, Latessa V, Spielvogel D, Hollier LH, Marin ML. Risk of spinal cord ischemia after endograft repair of thoracic aortic aneurysms. J Vasc Surg. 2001; 34: 997–1003.
    OpenUrlCrossRefPubMed
  71. ↵
    Burks JA Jr, Faries PL, Gravereaux EC, Hollier LH, Marin ML. Endovascular repair of thoracic aortic aneurysms: stent-graft fixation across the aortic arch vessels. Ann Vasc Surg. 2002; 16: 24–28.
    OpenUrlCrossRefPubMed
  72. ↵
    Gorich J, Asquan Y, Seifarth H, Kramer S, Kapfer X, Orend KH, Sunder-Plassmann L, Pamler R. Initial experience with intentional stent-graft coverage of the subclavian artery during endovascular thoracic aortic repairs. J Endovasc Ther. 2002; 9 (suppl 2): II39–II43.
    OpenUrlPubMed
  73. ↵
    Tiesenhausen K, Hausegger KA, Oberwalder P, Mahla E, Tomka M, Allmayer T, Baumann A, Hessinger M. Left subclavian artery management in endovascular repair of thoracic aortic aneurysms and aortic dissections. J Card Surg. 2003; 18: 429–435.
    OpenUrlCrossRefPubMed
  74. ↵
    Dake MD, Miller DC, Semba CP, Mitchell RS, Walker PJ, Liddell RP. Transluminal placement of endovascular stent-grafts for the treatment of descending thoracic aortic aneurysms. N Engl J Med. 1994; 331: 1729–1734.
    OpenUrlCrossRefPubMed
  75. ↵
    Dake MD, Miller DC, Mitchell RS, Semba CP, Moore KA, Sakai T. The “first generation” of endovascular stent-grafts for patients with aneurysms of the descending thoracic aorta. J Thorac Cardiovasc Surg. 1998; 116: 689–703.
    OpenUrlCrossRefPubMed
  76. ↵
    Ehrlich M, Grabenwoeger M, Cartes-Zumelzu F, Grimm M, Petzl D, Lammer J, Thurnher S, Wolner E, Havel M. Endovascular stent graft repair for aneurysms on the descending thoracic aorta. Ann Thorac Surg. 1998; 66: 19–24.
    OpenUrlCrossRefPubMed
  77. ↵
    Cartes-Zumelzu F, Lammer J, Kretschmer G, Hoelzenbein T, Grabenwoger M, Thurnher S. Endovascular repair of thoracic aortic aneurysms. Semin Interv Cardiol. 2000; 5: 53–57.
    OpenUrlPubMed
  78. ↵
    Grabenwoger M, Hutschala D, Ehrlich MP, Cartes-Zumelzu F, Thurnher S, Lammer J, Wolner E, Havel M. Thoracic aortic aneurysms: treatment with endovascular self-expandable stent grafts. Ann Thorac Surg. 2000; 69: 441–445.
    OpenUrlCrossRefPubMed
  79. ↵
    Greenberg R, Resch T, Nyman U, Lindh M, Brunkwall J, Brunkwall P, Malina M, Koul B, Lindblad B, Ivancev K. Endovascular repair of descending thoracic aortic aneurysms: an early experience with intermediate-term follow-up. J Vasc Surg. 2000; 31: 147–156.
    OpenUrlCrossRefPubMed
  80. ↵
    Temudom T, D’Ayala M, Marin ML, Hollier LH, Parsons R, Teodorescu V, Mitty H, Ahn J, Falk A, Kahn R, Griepp R. Endovascular grafts in the treatment of thoracic aortic aneurysms and pseudoaneurysms. Ann Vasc Surg. 2000; 14: 230–238.
    OpenUrlCrossRefPubMed
  81. ↵
    Najibi S, Terramani TT, Weiss VJ, MacDonald MJ, Lin PH, Redd DC, Martin LG, Chaikof EL, Lumsden AB. Endoluminal versus open treatment of descending thoracic aortic aneurysms. J Vasc Surg. 2002; 36: 732–737.
    OpenUrlCrossRefPubMed
  82. ↵
    Heijmen RH, Deblier IG, Moll FL, Dossche KM, van den Berg JC, Overtoom TT, Ernst SM, Schepens MA. Endovascular stent-grafting for descending thoracic aortic aneurysms. Eur J Cardiothorac Surg. 2002; 21: 5–9.
    OpenUrlAbstract/FREE Full Text
  83. ↵
    Schoder M, Cartes-Zumelzu F, Grabenwoger M, Cejna M, Funovics M, Krenn CG, Hutschala D, Wolf F, Thurnher S, Kretschmer G, Lammer J. Elective endovascular stent-graft repair of atherosclerotic thoracic aortic aneurysms: clinical results and midterm follow-up. AJR Am J Roentgenol. 2003; 180: 709–715.
    OpenUrlPubMed
  84. ↵
    Marin ML, Hollier LH, Ellozy SH, Spielvogel D, Mitty H, Griepp R, Lookstein RA, Carroccio A, Morrissey NJ, Teodorescu VJ, Jacobs TS, Minor ME, Sheahan CM, Chae K, Oak J, Cha A. Endovascular stent graft repair of abdominal and thoracic aortic aneurysms: a ten-year experience with 817 patients. Ann Surg. 2003; 238: 586–593.
    OpenUrlPubMed
  85. ↵
    Lepore V, Lonn L, Delle M, Mellander S, Radberg G, Risberg B. Treatment of descending thoracic aneurysms by endovascular stent grafting. J Card Surg. 2003; 18: 436–443.
    OpenUrlCrossRefPubMed
  86. ↵
    Sunder-Plassmann L, Scharrer-Pamler R, Liewald F, Kapfer X, Gorich J, Orend KH. Endovascular exclusion of thoracic aortic aneurysms: mid-term results of elective treatment and in contained rupture. J Card Surg. 2003; 18: 367–374.
    OpenUrlCrossRefPubMed
  87. ↵
    Bergeron P, De Chaumaray T, Gay J, Douillez V. Endovascular treatment of thoracic aortic aneurysms. J Cardiovasc Surg (Torino). 2003; 44: 349–361.
    OpenUrlPubMed
  88. ↵
    Czerny M, Cejna M, Hutschala D, Fleck T, Holzenbein T, Schoder M, Lammer J, Zimpfer D, Ehrlich M, Wolner E, Grabenwoger M. Stent-graft placement in atherosclerotic descending thoracic aortic aneurysms: midterm results. J Endovasc Ther. 2004; 11: 26–32.
    OpenUrlCrossRefPubMed
  89. ↵
    Makaroun MS, Dillavou ED, Kee ST, Sicard G, Chaikor E, Bavaria J, Williams D, Cambria RP, Mitchell RS. Endovascular treatment of thoracic aortic aneurysms: results of the phase II multicenter trial of the GORE TAG thoracic endoprosthesis. J Vasc Surg. 2005; 41: 1–9
    OpenUrlCrossRefPubMed
  90. ↵
    Leurs LJ, Bell R, Degrieck Y, Thomas S, Hobo R, Lundbom J. Endovascular treatment of thoracic aortic diseases: combined experience from the EUROSTAR and United Kingdom Thoracic Endograft registries. J Vasc Surg. 2004; 40: 670–679.
    OpenUrlCrossRefPubMed
  91. ↵
    Mitchell RS, Miller DC, Dake MD. Stent-graft repair of thoracic aortic aneurysms. Semin Vasc Surg. 1997; 10: 257–271.
    OpenUrlPubMed
  92. ↵
    Carroccio A, Marin ML, Ellozy S, Hollier LH. Pathophysiology of paraplegia following endovascular thoracic aortic aneurysm repair. J Card Surg. 2003; 18: 359–366.
    OpenUrlCrossRefPubMed
  93. ↵
    Thurnher SA, Grabenwoger M. Endovascular treatment of thoracic aortic aneurysms: a review. Eur Radiol. 2002; 12: 1370–1387.
    OpenUrlCrossRefPubMed
  94. ↵
    Resch T, Koul B, Dias NV, Lindblad B, Ivancev K. Changes in aneurysm morphology and stent-graft configuration after endovascular repair of aneurysms of the descending thoracic aorta. J Thorac Cardiovasc Surg. 2001; 122: 47–52.
    OpenUrlCrossRefPubMed
  95. ↵
    Buth J, Harris PL, van Marrewijk C, Fransen G. The significance and management of different types of endoleaks. Semin Vasc Surg. 2003; 16: 95–102.
    OpenUrlCrossRefPubMed
  96. ↵
    Chuter TA, Faruqi RM, Sawhney R, Reilly LM, Kerlan RB, Canto CJ, Lukaszewicz GC, Laberge JM, Wilson MW, Gordon RL, Wall SD, Rapp J, Messina LM. Endoleak after endovascular repair of abdominal aortic aneurysm. J Vasc Surg. 2001; 34: 98–105.
    OpenUrlCrossRefPubMed
  97. ↵
    Kato N, Semba CP, Dake MD. Embolization of perigraft leaks after endovascular stent-graft treatment of aortic aneurysms. J Vasc Interv Radiol. 1996; 7: 805–811.
    OpenUrlPubMed
  98. ↵
    Hausegger KA, Oberwalder P, Tiesenhausen K, Tauss J, Stanger O, Schedlbauer P, Deutschmann H, Rigler B. Intentional left subclavian artery occlusion by thoracic aortic stent-grafts without surgical transposition. J Endovasc Ther. 2001; 8: 472–476.
    OpenUrlCrossRefPubMed
  99. ↵
    Stanley BM, Semmens JB, Lawrence-Brown MM, Goodman MA, Hartley DE. Fenestration in endovascular grafts for aortic aneurysm repair: new horizons for preserving blood flow in branch vessels. J Endovasc Ther. 2001; 8: 16–24.
    OpenUrlCrossRefPubMed
  100. ↵
    Inoue K, Hosokawa H, Iwase T, Sato M, Yoshida Y, Ueno K, Tsubokawa A, Tanaka T, Tamaki S, Suzuki T. Aortic arch reconstruction by transluminally placed endovascular branched stent graft. Circulation. 1999; 100 (suppl II): II-316–II-321.
    OpenUrlPubMed
  101. ↵
    McWilliams RG, Murphy M, Hartley D, Lawrence-Brown MM, Harris PL. In situ stent-graft fenestration to preserve the left subclavian artery. J Endovasc Ther. 2004; 11: 170–174.
    OpenUrlCrossRefPubMed
  102. ↵
    Heinemann MK, Buehner B, Jurmann MJ, Borst HG. Use of the “elephant trunk technique” in aortic surgery. Ann Thorac Surg. 1995; 60: 2–6.
    OpenUrlCrossRefPubMed
  103. ↵
    Fann JI, Dake MD, Semba CP, Liddell RP, Pfeffer TA, Miller DC. Endovascular stent-grafting after arch aneurysm repair using the “elephant trunk.” Ann Thorac Surg. 1995; 60: 1102–1105.
    OpenUrlCrossRefPubMed
  104. ↵
    Dake MD, Kato N, Mitchell RS, Semba CP, Razavi MK, Shimono T, Hirano T, Takeda K, Yada I, Miller DC. Endovascular stent-graft placement for the treatment of acute aortic dissection. N Engl J Med. 1999; 340: 1546–1552.
    OpenUrlCrossRefPubMed
  105. ↵
    Kato N, Dake MD, Miller DC, Semba CP, Mitchell RS, Razavi MK, Kee ST. Traumatic thoracic aortic aneurysm: treatment with endovascular stent-grafts. Radiology. 1997; 205: 657–662.
    OpenUrlCrossRefPubMed
  106. ↵
    Eggebrecht H, Baumgart D, Schmermund A, Herold U, Hunold P, Jakob H, Erbel R. Penetrating atherosclerotic ulcer of the aorta: treatment by endovascular stent-graft placement. Curr Opin Cardiol. 2003; 18: 431–435.
    OpenUrlCrossRefPubMed
  107. ↵
    Kato N, Hirano T, Ishida M, Shimono T, Cheng SH, Yada I, Takeda K. Acute and contained rupture of the descending thoracic aorta: treatment with endovascular stent grafts. J Vasc Surg. 2003; 37: 100–105.
    OpenUrlCrossRefPubMed
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Circulation
September 13, 2005, Volume 112, Issue 11
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    Endovascular Repair of Abdominal and Thoracic Aortic Aneurysms
    Barry T. Katzen, Michael D. Dake, Alexandra A. MacLean and David S. Wang
    Circulation. 2005;112:1663-1675, originally published September 12, 2005
    https://doi.org/10.1161/CIRCULATIONAHA.105.541284

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    Endovascular Repair of Abdominal and Thoracic Aortic Aneurysms
    Barry T. Katzen, Michael D. Dake, Alexandra A. MacLean and David S. Wang
    Circulation. 2005;112:1663-1675, originally published September 12, 2005
    https://doi.org/10.1161/CIRCULATIONAHA.105.541284
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