Electrolyte Studies in Heart Failure
II. Extracellular Factors in the Pathogenesis of Congestive Edema
Indirect metabolic studies and direct muscle biopsy studies have indicated diminution of intracellular electrolyte concentration during congestive heart failure explainable by extrusion of these electrolytes due to increase in osmolarity within the cells. Acute and chronic physical and circulatory stress in cardiac patients produced an elevation of plasma sodium concentration indicative of a concomittant increase in osmolarity of the extracellular fluid.
- © 1955 American Heart Association, Inc.