Percutaneous Aortic Valve Replacement in Animals
In 2000, we percutaneously implanted a biological valve in the pulmonary artery of animals. A year later, we repeated the procedure in humans. Harvested from the bovine jugular vein, this valve was tested in vitro to assess its function when submitted to a diastolic pressure of 100 mm Hg, as well as its durability. The valve is shown in the closed and opened positions in the pump in Figure 1 and in Movie I. Because these tests were encouraging, we decided to implant this valve in the aorta.
Through the right carotid artery, the valve was inserted crimped onto a balloon catheter and advanced in the aortic valve. The valve was then deployed in an orthotopic position, trapping the native valve between the aortic wall and the supporting structure of the new valve. Immediately after the implantation and during the 2 months of follow-up, angiograms confirmed the perfect function of the valve and the permeability of the coronary arteries, as shown in Figure 2 and in Movie II.
Movies I and II are available as an online-only Data Supplement at http://www.circulationaha.org.
The editor of Images in Cardiovascular Medicine is Hugh A. McAllister, Jr, MD, Chief, Department of Pathology, St Luke’s Episcopal Hospital and Texas Heart Institute, and Clinical Professor of Pathology, University of Texas Medical School and Baylor College of Medicine.
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