Skip to main content
  • American Heart Association
  • Science Volunteer
  • Warning Signs
  • Advanced Search
  • Donate

  • Home
  • About this Journal
    • Editorial Board
    • General Statistics
    • Circulation Doodle
      • Doodle Gallery
      • Circulation Cover Doodle
        • → Blip the Doodle
    • Information for Advertisers
    • Author Reprints
    • Commercial Reprints
    • Customer Service and Ordering Information
    • Subscribe to AHA Journals
  • All Issues
  • Subjects
    • All Subjects
    • Arrhythmia and Electrophysiology
    • Basic, Translational, and Clinical Research
    • Critical Care and Resuscitation
    • Epidemiology, Lifestyle, and Prevention
    • Genetics
    • Heart Failure and Cardiac Disease
    • Hypertension
    • Imaging and Diagnostic Testing
    • Intervention, Surgery, Transplantation
    • Quality and Outcomes
    • Stroke
    • Vascular Disease
  • Browse Features
    • AHA Guidelines and Statements
      • Recently Published Guidelines
    • Bridging Disciplines
    • Circulation at Major Meetings
    • Special Themed Issues
    • Global Impact of the 2017 ACC/AHA Hypertension Guidelines
    • Circulation Supplements
    • Cardiovascular Case Series
    • ECG Challenge
    • Hospitals of History
      • Brigham and Women's Hospital
      • Hartford Hospital
      • Hospital Santa Maria del Popolo, Naples, Italy
      • Instituto do Coração-INCOR (São Paulo, Brasil)
      • Minneapolis City Hospital
      • Parkland Hospital: Dallas, Texas
      • Pennsylvania Hospital, Philadelphia
      • Pitié-Salpêtrière Hospital
      • Royal Infirmary of Edinburgh, Scotland
      • Tufts Medical Center
      • University of Michigan
      • Uppsala University Hospital
      • Vassar Brothers Medical Center (Poughkeepsie, NY)
      • Wroclaw Medical University
      • Women's College Hospital, Toronto, Canada
      • Henry Ford Hospital, Detroit, Michigan
      • Instituto Nacional de Cardiología Ignacio Chávez – INCICh México City, México
      • Kuang-Tien General Hospital (Taichug, Taiwan)
    • On My Mind
    • Podcast Archive
    • → Subscribe to Circulation on the Run
    • →Circulation FIT Podcast 2018
    • → #FITFAVs
  • Resources
    • Instructions for Authors
      • Accepted Manuscripts
      • Revised Manuscripts
    • → Article Types
    • → General Preparation Instructions
    • → Research Guidelines
    • → How to Submit a Manuscript
    • Journal Policies
    • Permissions and Rights Q&A
    • Submission Sites
    • Circulation CME
    • AHA Journals RSS Feeds
    • International Users
    • AHA Newsroom
  • AHA Journals
    • AHA Journals Home
    • Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
    • Circulation
    • → Circ: Arrhythmia and Electrophysiology
    • → Circ: Genomic and Precision Medicine
    • → Circ: Cardiovascular Imaging
    • → Circ: Cardiovascular Interventions
    • → Circ: Cardiovascular Quality & Outcomes
    • → Circ: Heart Failure
    • Circulation Research
    • Hypertension
    • Stroke
    • Journal of the American Heart Association
  • Facebook
  • Twitter

  • My alerts
  • Sign In
  • Join

  • Advanced search

Header Publisher Menu

  • American Heart Association
  • Science Volunteer
  • Warning Signs
  • Advanced Search
  • Donate

Circulation

  • My alerts
  • Sign In
  • Join

  • Facebook
  • Twitter
  • Home
  • About this Journal
    • Editorial Board
    • General Statistics
    • Circulation Doodle
    • Information for Advertisers
    • Author Reprints
    • Commercial Reprints
    • Customer Service and Ordering Information
    • Subscribe to AHA Journals
  • All Issues
  • Subjects
    • All Subjects
    • Arrhythmia and Electrophysiology
    • Basic, Translational, and Clinical Research
    • Critical Care and Resuscitation
    • Epidemiology, Lifestyle, and Prevention
    • Genetics
    • Heart Failure and Cardiac Disease
    • Hypertension
    • Imaging and Diagnostic Testing
    • Intervention, Surgery, Transplantation
    • Quality and Outcomes
    • Stroke
    • Vascular Disease
  • Browse Features
    • AHA Guidelines and Statements
    • Bridging Disciplines
    • Circulation at Major Meetings
    • Special Themed Issues
    • Global Impact of the 2017 ACC/AHA Hypertension Guidelines
    • Circulation Supplements
    • Cardiovascular Case Series
    • ECG Challenge
    • Hospitals of History
    • On My Mind
    • Podcast Archive
    • → Subscribe to Circulation on the Run
    • →Circulation FIT Podcast 2018
    • → #FITFAVs
  • Resources
    • Instructions for Authors
    • → Article Types
    • → General Preparation Instructions
    • → Research Guidelines
    • → How to Submit a Manuscript
    • Journal Policies
    • Permissions and Rights Q&A
    • Submission Sites
    • Circulation CME
    • AHA Journals RSS Feeds
    • International Users
    • AHA Newsroom
  • AHA Journals
    • AHA Journals Home
    • Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
    • Circulation
    • → Circ: Arrhythmia and Electrophysiology
    • → Circ: Genomic and Precision Medicine
    • → Circ: Cardiovascular Imaging
    • → Circ: Cardiovascular Interventions
    • → Circ: Cardiovascular Quality & Outcomes
    • → Circ: Heart Failure
    • Circulation Research
    • Hypertension
    • Stroke
    • Journal of the American Heart Association
Clinical Investigation and Reports

Prevention of Inflammation-Induced Endothelial Dysfunction

A Novel Vasculo-Protective Action of Aspirin

Rajesh K. Kharbanda, Benjamin Walton, Meredith Allen, Nigel Klein, Aroon D. Hingorani, Raymond J. MacAllister, Patrick Vallance
Download PDF
https://doi.org/10.1161/01.CIR.0000017863.52347.6C
Circulation. 2002;105:2600-2604
Originally published May 13, 2002
Rajesh K. Kharbanda
From the Centre for Clinical Pharmacology (R.K.K., A.D.H., R.J.M., P.V.), British Heart Foundation Laboratories, University College London; Cardiothoracic Unit (B.W.), Great Ormond Street Hospital for Children; and Immunobiology Unit (M.A., N.K.), Institute of Child Health, University College London, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benjamin Walton
From the Centre for Clinical Pharmacology (R.K.K., A.D.H., R.J.M., P.V.), British Heart Foundation Laboratories, University College London; Cardiothoracic Unit (B.W.), Great Ormond Street Hospital for Children; and Immunobiology Unit (M.A., N.K.), Institute of Child Health, University College London, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Meredith Allen
From the Centre for Clinical Pharmacology (R.K.K., A.D.H., R.J.M., P.V.), British Heart Foundation Laboratories, University College London; Cardiothoracic Unit (B.W.), Great Ormond Street Hospital for Children; and Immunobiology Unit (M.A., N.K.), Institute of Child Health, University College London, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nigel Klein
From the Centre for Clinical Pharmacology (R.K.K., A.D.H., R.J.M., P.V.), British Heart Foundation Laboratories, University College London; Cardiothoracic Unit (B.W.), Great Ormond Street Hospital for Children; and Immunobiology Unit (M.A., N.K.), Institute of Child Health, University College London, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aroon D. Hingorani
From the Centre for Clinical Pharmacology (R.K.K., A.D.H., R.J.M., P.V.), British Heart Foundation Laboratories, University College London; Cardiothoracic Unit (B.W.), Great Ormond Street Hospital for Children; and Immunobiology Unit (M.A., N.K.), Institute of Child Health, University College London, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raymond J. MacAllister
From the Centre for Clinical Pharmacology (R.K.K., A.D.H., R.J.M., P.V.), British Heart Foundation Laboratories, University College London; Cardiothoracic Unit (B.W.), Great Ormond Street Hospital for Children; and Immunobiology Unit (M.A., N.K.), Institute of Child Health, University College London, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Patrick Vallance
From the Centre for Clinical Pharmacology (R.K.K., A.D.H., R.J.M., P.V.), British Heart Foundation Laboratories, University College London; Cardiothoracic Unit (B.W.), Great Ormond Street Hospital for Children; and Immunobiology Unit (M.A., N.K.), Institute of Child Health, University College London, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Tables
  • Info & Metrics
  • eLetters

Jump to

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgments
    • References
  • Figures & Tables
  • Info & Metrics
  • eLetters
Loading

Abstract

Background— Inflammation and infection may initiate and promote atherosclerosis or its complications by adverse effects on the vascular endothelium. The mechanisms by which aspirin reduces cardiovascular risk might involve anti-inflammatory actions or direct effects on the endothelium in addition to its antiplatelet action. We investigated the role of aspirin in modulating endothelial dysfunction induced by an experimental inflammatory stimulus.

Methods and Results— An inflammatory response was generated in healthy volunteers by Salmonella typhi vaccination. Venous occlusion plethysmography was used to assess resistance vessel responses (16 hours before and 8 hours after vaccination) to the endothelium-dependent dilator bradykinin (BK) and the endothelium-independent dilator glyceryl-trinitrate (GTN). Twelve subjects were randomized to receive either aspirin 1.2 g orally or placebo 2 hours before vaccination. After vaccination alone there was suppression of the response to BK in the placebo group (P=0.01), with no change in response to GTN. In the aspirin group there was no change in the response to either BK or GTN after vaccination. Aspirin treatment prevented vaccine-induced elevation of interleukin-1 receptor antagonist but enhanced the generation of tumor necrosis factor-α compared with placebo. In an additional 5 individuals, local intrabrachial aspirin (10 mg/min for 15 minutes) failed to restore responses to BK after vaccination.

Conclusions— Experimental inflammation produces endothelial dysfunction, which can be prevented by pretreatment with aspirin. Locally administered aspirin does not reverse vaccine-induced endothelial dysfunction once established. The protective effects of aspirin on inflammation-induced endothelial dysfunction may be through modulation of the cytokine cascade.

  • arteries
  • aspirin
  • bradykinin
  • endothelium
  • inflammation

Received January 16, 2002; revision received March 27, 2002; accepted March 27, 2002.

View Full Text
Back to top
Previous ArticleNext Article

This Issue

Circulation
June 4, 2002, Volume 105, Issue 22
  • Table of Contents
Previous ArticleNext Article

Jump to

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgments
    • References
  • Figures & Tables
  • Info & Metrics
  • eLetters

Article Tools

  • Print
  • Citation Tools
    Prevention of Inflammation-Induced Endothelial Dysfunction
    Rajesh K. Kharbanda, Benjamin Walton, Meredith Allen, Nigel Klein, Aroon D. Hingorani, Raymond J. MacAllister and Patrick Vallance
    Circulation. 2002;105:2600-2604, originally published May 13, 2002
    https://doi.org/10.1161/01.CIR.0000017863.52347.6C

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
  •  Download Powerpoint
  • Article Alerts
    Log in to Email Alerts with your email address.
  • Save to my folders

Share this Article

  • Email

    Thank you for your interest in spreading the word on Circulation.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Prevention of Inflammation-Induced Endothelial Dysfunction
    (Your Name) has sent you a message from Circulation
    (Your Name) thought you would like to see the Circulation web site.
  • Share on Social Media
    Prevention of Inflammation-Induced Endothelial Dysfunction
    Rajesh K. Kharbanda, Benjamin Walton, Meredith Allen, Nigel Klein, Aroon D. Hingorani, Raymond J. MacAllister and Patrick Vallance
    Circulation. 2002;105:2600-2604, originally published May 13, 2002
    https://doi.org/10.1161/01.CIR.0000017863.52347.6C
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

Related Articles

Cited By...

Subjects

  • Epidemiology, Lifestyle, and Prevention
    • Primary Prevention
    • Secondary Prevention
    • Epidemiology
  • Intervention, Surgery, Transplantation
    • Treatment
  • Basic, Translational, and Clinical Research
    • Platelets
    • Mechanisms
    • Endothelium/Vascular Type/Nitric Oxide
  • Cardiology
    • Etiology
      • Acute coronary syndromes
  • Vascular Disease
    • Acute Coronary Syndromes

Circulation

  • About Circulation
  • Instructions for Authors
  • Circulation CME
  • Statements and Guidelines
  • Meeting Abstracts
  • Permissions
  • Journal Policies
  • Email Alerts
  • Open Access Information
  • AHA Journals RSS
  • AHA Newsroom

Editorial Office Address:
200 Fifth Avenue, Suite 1020
Waltham, MA 02451
email: circ@circulationjournal.org
 

Information for:
  • Advertisers
  • Subscribers
  • Subscriber Help
  • Institutions / Librarians
  • Institutional Subscriptions FAQ
  • International Users
American Heart Association Learn and Live
National Center
7272 Greenville Ave.
Dallas, TX 75231

Customer Service

  • 1-800-AHA-USA-1
  • 1-800-242-8721
  • Local Info
  • Contact Us

About Us

Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The need for our work is beyond question. Find Out More about the American Heart Association

  • Careers
  • SHOP
  • Latest Heart and Stroke News
  • AHA/ASA Media Newsroom

Our Sites

  • American Heart Association
  • American Stroke Association
  • For Professionals
  • More Sites

Take Action

  • Advocate
  • Donate
  • Planned Giving
  • Volunteer

Online Communities

  • AFib Support
  • Garden Community
  • Patient Support Network
  • Professional Online Network

Follow Us:

  • Follow Circulation on Twitter
  • Visit Circulation on Facebook
  • Follow Circulation on Google Plus
  • Follow Circulation on Instagram
  • Follow Circulation on Pinterest
  • Follow Circulation on YouTube
  • Rss Feeds
  • Privacy Policy
  • Copyright
  • Ethics Policy
  • Conflict of Interest Policy
  • Linking Policy
  • Diversity
  • Careers

©2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a qualified 501(c)(3) tax-exempt organization.
*Red Dress™ DHHS, Go Red™ AHA; National Wear Red Day ® is a registered trademark.

  • PUTTING PATIENTS FIRST National Health Council Standards of Excellence Certification Program
  • BBB Accredited Charity
  • Comodo Secured