Fen/Phen and Valvular Heart Disease: The Final Link Has Now Been Established
To the Editor:
The findings reported by Shively et al1 that dexfenfluramine-induced valvulopathy may regress after cessation of drug use received further support from the latest report from the Mayo Clinic.2 These 2 reports are extremely important not only from the prognostic standpoint, but also from the diagnostic point of view.
Recently, published reports challenged the well-established association between dexfenfluramine use and valvular regurgitation.3 4 5 However, the reports by Shively et al1 and Hensrud et al2 should dispel any doubt, because the Koch’s postulates have now been fulfilled.
- Copyright © 2000 by American Heart Association