Circulation Online Only
February 15, 2000
Circulation is pleased to announce a new initiative in publishing: Circulation Online Only. In an effort to publish various types of articles more rapidly, we are looking to put the Internet to its highest and best use and take full advantage of electronic publication. Thus, we now have a section of our journal entitled Circulation Online Only. The articles to be published in this section will be identified, and when applicable, an abstract published, on the special page in the print journal differentiated by a red border. Each article that appears in Circulation Online Only is indexed in Index Medicus, MEDLINE, and PubMed. Each article will also appear in the Table of Contents on the cover, denoted by a red star, and in the Table of Contents within the journal, denoted by the letter e in front of the page number.
We will now present the following articles Online Only: Letters to the Editor, Book Reviews, Clinicopathological Conferences, and News. This will allow more rapid publication of these contributions and their presentation to the readership in a more timely manner.
In an effort to reduce the time required for the publication of manuscripts in Circulation and to keep the journal small in size and more readable, the Editors have decided to present most of the “Materials and Methods” portion of manuscripts published in Circulation as Online Only pages beginning in March 2000. This will allow us to save several pages in each issue of the printed journal and make it possible to move up in time manuscripts now waiting to be published. We shall monitor this effort closely and shall initially regard it as a temporary alteration in our publication method. However, if it is useful and worthwhile and does not detract from the printed journal, we shall adopt this procedure more permanently in the future.
Synthetic Inhibitors of Platelet Glycoprotein IIb/IIIa in Clinical Development
Marc Verstraete, MD, PhD
Abstract—The recognition of the important role of platelets in the pathogenesis of ischemic cardiac and cerebral events has stimulated the search for more potent antiplatelet agents than aspirin and phosphodiesterase inhibitors. In addition to ticlopidine and clopidogrel, which inhibit only ADP-induced platelet activation, considerable attention is directed to inhibitors of the platelet glycoprotein (GP) IIb/IIIa receptor for fibrinogen that block platelet aggregation in response to all agonists. The remarkable efficacy of monoclonal antibodies to glycoprotein IIb/IIIa was soon followed by the development of synthetic GP IIb/IIIa inhibitors, of which several are orally active, nonpeptide compounds. Nine GP IIb/IIIa inhibitors are in clinical development and are the topic of this review. (Circulation. 2000;101:e76–e80.)
Images in Cardiovascular Medicine
Polymorphic Ventricular Tachycardia and Repolarization Abnormalities Accompanying Intracerebral Hemorrhage
Haim D. Danenberg, MD; Yonathan Hasin, MD (Circulation. 2000;101:e81.)
- Copyright © 2000 by American Heart Association