Percutaneous Myocardial Gene Transfer of phVEGF-2
Gene transfer of phVEGF-2, an endothelial cell mitogen previously shown to promote angiogenesis in preclinical animal studies, is intended to promote collateral vessel development to the ischemic lateral LV wall. The strategy of gene delivery used in this case is designed to exploit the fact that muscle, particularly myocardium, yields relatively higher levels of gene expression than other tissue types; electromechanical mapping was used in this case to guide injection to sites of myocardial ischemia, because ischemic muscle yields even higher levels of gene expression. The patient was an 82-year-old man with coronary heart disease, including an old anteroseptal myocardial infarction (MI), previous coronary artery bypass surgery, and chronic angina refractory to medical therapy.
The editor of Images in Cardiovascular Medicine is Hugh A. McAllister, Jr, MD, Chief, Department of Pathology, St Luke’s Episcopal Hospital and Texas Heart Institute, and Clinical Professor of Pathology, University of Texas Medical School and Baylor College of Medicine.
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