Insertion/Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Hypertension
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To the Editor:
Recently, an analysis was performed using a prospective, longitudinal, population-based sample in which the insertion/deletion (I/D) polymorphism of the ACE gene was postulated as a sex-specific candidate gene for hypertension.1 A significant association between hypertension in males and the ACE DD genotype was observed after adjustment for all confounders (OR 1.59, P=0.02), whereas linkage between the DD genotype and diastolic blood pressure (DBP) in men was significant only when adjusted for age alone (P=0.03 and P=0.16 after …