Human Basic Fibroblast Growth Factor Induces Angiogenesis in Hen Eggs and Rat Hearts
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To the Editor:
In the February 24, 1998, issue of Circulation, Schumacher et al1 report on their work concerning the production of human basic fibroblast growth factor (FGF-1), 2 series of animal experiments using FGF-1, and the clinical use of the growth factor in patients undergoing CABG surgery. They have to be congratulated for their persistent effort of genetically producing, experimentally testing, and clinically applying an angiogenic growth factor in patients with coronary artery disease (CHD) for the first time. The authors themselves say at one point in the discussion that the possibility of inducing angiogenesis in the human heart “has been widely discussed for …