Antibiotic Therapy of Bacterial Endocarditis
VI. Subacute Enterococcal Endocarditis: Clinical, Pathologic and Therapeutic Consideration of 33 Cases
Thirty-three cases of enterococcal endocarditis encountered during the decade from January 1944 through December 1953 are reviewed. In vitro studies indicate that penicillin and streptomycin are the best antibiotic pair for bactericidal effect. Twelve of the last 14 patients were cured (86 per cent), 10 with combined therapy. The cure rate in enterococcal endocarditis now approximates that of endocarditis caused by penicillin-sensitive streptococci. A maximal number of cures is achieved by individualization of therapy. The daily dosage of penicillin and the duration of combined penicillin-streptomycin therapy should be guided by in vitro bactericidal tests employing the patient's strain of enterococcus.
- © 1954 American Heart Association, Inc.