The Effect of Diphenylhydantoin Sodium (Dilantin), Procaine Hydrochloride, Procaine Amide Hydrochloride, and Quinidine Hydrochloride upon Ouabain-Induced Ventricular Tachycardia in Unanesthetized Dogs

Abstract

Ventricular tachycardia has been produced in unanesthetized dogs by the intravenous injection of ouabain, and the ability of various agents to produce reversion to normal sinus rhythm has been tested. Diphenylhydantoin sodium, procaine amide hydrochloride, procaine hydrochloride and quinidine hydrochloride were approximately equally effective; however the procaine hydrochloride effect was shorter and the drug was more toxic than the other three. It is suggested that diphenylhydantoin sodium may merit a trial for the treatment of digitalis-induced ventricular arrhythmias.