Studies of Tissue Response to Injections of Enzymes
III. Preliminary Report. Development of Subcutaneous "Nodules" and Tissue Hexosamine Changes in Rabbits Following a Single Subcutaneous Injection of Streptokinase
Since 1893, activation of the serum proteolytic enzymes has been accomplished by a variety of methods and agents. Activation of the serum proteolytic enzyme by means of streptokinase, the beta hemolytic streptococcal kinase, has been recently demonstrated. The significant plasma and tissue hexosamine changes, as well as the subcutaneous "nodules" which developed at the injection sites, resemble those observed in the trypsin treated group. Although trypsin and the serum proteolytic enzyme are not identical, they have many characteristics in common.
- © 1950 American Heart Association, Inc.