Anti-Adrenergic Effects of Nitroglycerin on the Heart
The therapeutic effect of nitroglycerin is generally attributed to its coronary dilator effect alone. In contrast, it could be shown that nitroglycerin also counteracts the chronotropic as well as the electrocardiographic T-wave depressing effects of epinephrine, arterenol and cardiac sympathin upon the heart. Accordingly, its therapeutic action in angina pectoris is suspected as being largely due to a chemical protection of the heart muscle against the chemically anoxia-producing effects of sympathomimetic amines.
- © 1950 American Heart Association, Inc.