Studies on Congestive Circulatory Failure
III. The Relation of Edema to Urinary Chlorides
Balance studies in chronic congestive circulatory failure showed marked depression of renal excretion of chloride and further depression when the intake of salt was elevated or when fluids were restricted. This defect may not be accompanied by diminished ability to excrete nitrogen. Although cardiac compensation was usually accompanied by chloride diuresis of proportionate degree, in over one-third of the cases there was evidence of excessive hydration without proportionate retention of salt. Although initiated by a cardiac disorder, congestive failure is mediated by disturbances in renal regulatory mechanisms of both salt and water balances suggesting that hormonal effects play a role.
- © 1950 American Heart Association, Inc.