Clinical Studies on Veratrum Alkaloids
I. The Action of Protoveratrine and Veratridine in Hypertension
The action of two pure veratrum alkaloids, veratridine and protoveratrine, in human hypertension is described for the first time. The vasodepressor reflex pathway involved in the response to these ester alkaloids is reviewed. Protoveratrine is found to produce a striking fall in blood pressure in both essential and renal hypertension after intravenous administration.
- © 1950 American Heart Association, Inc.