Genetics

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Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial HypertensionCLINICAL PERSPECTIVE
Fabrice Antigny, Aurélie Hautefort, Jolyane Meloche, Milia Belacel-Ouari, Boris Manoury, Catherine Rucker-Martin, Christine Péchoux, François Potus, Valérie Nadeau, Eve Tremblay, Grégoire Ruffenach, Alice Bourgeois, Peter Dorfmüller, Sandra Breuils-Bonnet, Elie Fadel, Benoît Ranchoux, Philippe Jourdon, Barbara Girerd, David Montani, Steeve Provencher, Sébastien Bonnet, Gérald Simonneau, Marc Humbert and Frédéric Perros

Circulation. 2016;133:1371-1385, originally published February 24, 2016
https://doi.org/10.1161/CIRCULATIONAHA.115.020951

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Mending a Darkened HeartAlkaptonuria Discovered During Aortic Valve Replacement
Mark J. Schuuring, Ben Delemarre, Ali M. Keyhan-Falsafi and Ivo A. van der Bilt

Circulation. 2016;133:e444-e445, originally published March 21, 2016
https://doi.org/10.1161/CIRCULATIONAHA.115.020194

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Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk EstimatesCLINICAL PERSPECTIVEEffect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial)
Iftikhar J. Kullo, Hayan Jouni, Erin E. Austin, Sherry-Ann Brown, Teresa M. Kruisselbrink, Iyad N. Isseh, Raad A. Haddad, Tariq S. Marroush, Khader Shameer, Janet E. Olson, Ulrich Broeckel, Robert C. Green, Daniel J. Schaid, Victor M. Montori and Kent R. Bailey

Circulation. 2016;133:1181-1188, originally published February 25, 2016
https://doi.org/10.1161/CIRCULATIONAHA.115.020109

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Renal Dysfunction, Rather Than Nonrenal Vascular Dysfunction, Mediates Salt-Induced HypertensionResponse to Hall
John E. Hall

Circulation. 2016;133:894-906, originally published February 29, 2016
https://doi.org/10.1161/CIRCULATIONAHA.115.018526

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Response to Letters Regarding Article, “Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia: The Role of Left Cardiac Sympathetic Denervation”
Gaetano M. De Ferrari, Veronica Dusi, Carla Spazzolini, J. Martijn Bos, Dominic J. Abrams, Charles I. Berul, Lia Crotti, Michael Eldar, Maria Kharlap, Asaad Khoury, Andrew D. Krahn, Antoine Leenhardt, Christopher R. Moir, Attilio Odero, Louise Olde Nordkamp, Thomas Paul, Ferran Rosés i Noguer, Maria Shkolnikova, Jan Till, Arthur A.M. Wilde, Michael J. Ackerman and Peter J. Schwartz

Circulation. 2016;133:e366-e367, originally published January 25, 2016
https://doi.org/10.1161/CIRCULATIONAHA.115.019465

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Opportunities for the Cardiovascular Community in the Precision Medicine Initiative
Svati H. Shah, Donna Arnett, Steven R. Houser, Geoffrey S. Ginsburg, Calum MacRae, Seema Mital, Joseph Loscalzo and Jennifer L. Hall

Circulation. 2016;133:226-231, originally published January 11, 2016
https://doi.org/10.1161/CIRCULATIONAHA.115.019475

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9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor–Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle CellsCLINICAL PERSPECTIVE
Naif A. M. Almontashiri, Darlène Antoine, Xun Zhou, Ragnar O. Vilmundarson, Sean X. Zhang, Kennedy N. Hao, Hsiao-Huei Chen and Alexandre F. R. Stewart

Circulation. 2015;132:1969-1978, originally published October 20, 2015
https://doi.org/10.1161/CIRCULATIONAHA.114.015023

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Transthyretin-Derived (ATTR) Amyloidotic Cardiomyopathy After Receiving a Domino Liver Allograft
Maarten P. van den Berg, Riemer H.J.A. Slart, Hans Blokzijl and Bouke P.C. Hazenberg

Circulation. 2015;132:e216-e217, originally published November 2, 2015
https://doi.org/10.1161/CIRCULATIONAHA.115.016264

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Segmental Aortic Stiffness in Children and Young Adults With Connective Tissue DisordersCLINICAL PERSPECTIVERelationships With Age, Aortic Size, Rate of Dilation, and Surgical Root Replacement
Ashwin Prakash, Himanshu Adlakha, Nicole Rabideau, Cara J. Hass, Shaine A. Morris, Tal Geva, Kimberlee Gauvreau, Michael N. Singh and Ronald V. Lacro

Circulation. 2015;132:595-602, originally published June 25, 2015
https://doi.org/10.1161/CIRCULATIONAHA.114.014934

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Clinical Management of Catecholaminergic Polymorphic Ventricular TachycardiaCLINICAL PERSPECTIVEThe Role of Left Cardiac Sympathetic Denervation
Gaetano M. De Ferrari, Veronica Dusi, Carla Spazzolini, J. Martijn Bos, Dominic J. Abrams, Charles I. Berul, Lia Crotti, Andrew M. Davis, Michael Eldar, Maria Kharlap, Asaad Khoury, Andrew D. Krahn, Antoine Leenhardt, Christopher R. Moir, Attilio Odero, Louise Olde Nordkamp, Thomas Paul, Ferran Rosés i Noguer, Maria Shkolnikova, Jan Till, Arthur A.M. Wilde, Michael J. Ackerman and Peter J. Schwartz

Circulation. 2015;131:2185-2193, originally published May 27, 2015
https://doi.org/10.1161/CIRCULATIONAHA.115.015731

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