Published Online
on February 11, 2002

A more recent version of this article appeared on March 5, 2002

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Submitted on November 29, 2001
Revised on December 21, 2001
Accepted on December 21, 2001

Patients With Glanzmann Thrombasthenia Lacking Platelet Glycoprotein _IIbß₃ (GPIIb/IIIa) and _vß₃ Receptors Are Not Protected From Atherosclerosis

O. Shpilberg MD, MPH, I. Rabi MD, K. Schiller , R. Walden MD, D. Harats MD, K. S. Tyrrell PhD, B. Coller MD, and U. Seligsohn MD^*

From the Institute of Thrombosis and Hemostasis (O.S., U.S.), Laboratory of Vascular Surgery (I.R., R.V.), and the Branco and Eva Weiss Institute of Lipid and Atherosclerosis Research (D.H.), Sheba Medical Center, Tel-Hashomer, Israel; the Epidemiology Ultrasound Research Laboratory, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.S., K.S.T.); and the Department of Medicine, Mount Sinai Hospital, New York, NY (B.C.).

^* To whom correspondence should be addressed. E-mail: seligson{at}sheba.health.gov.il.

Background—Platelets have been suggested to play a role in the early development of atherosclerosis. As one test of this hypothesis, we assessed whether patients with Glanzmann thrombasthenia who lack platelet glycoprotein _IIbß₃ (GPIIb/IIIa) complexes or both _IIbß₃ and the more ubiquitous _vß₃ cell membrane complexes are protected from development of atherosclerosis.

Methods and Results—Seven patients with Glanzmann thrombasthenia, 45 to 66 years of age, underwent bilateral carotid artery ultrasonography and screening for risk factors of atherosclerosis. Findings consistent with early atherosclerosis evaluated by measurement of intima-media thickness and presence of atherosclerotic plaques were observed in 6 of the 7 patients. Intima-media thickness values higher than the 75th and 90th percentiles of age- and sex-matched white control subjects of the Atherosclerosis Risk in Communities (ARIC) study were observed in 30 and 8 of 56 carotid artery measurements, respectively. Five of the 6 patients with signs consistent with early atherosclerosis lacked both _IIbß₃ and _vß₃ complexes and 1 only lacked _IIbß₃.

Conclusions—Glanzmann thrombasthenia does not protect affected individuals from development of atherosclerosis.

Key words: atherosclerosis • carotid arteries • imaging • platelets

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