on January 14, 2002
Published online before print January 14, 2002, doi: 10.1161/hc0702.103977
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on August 22, 2001
From the Division of Cardiology (C.A.K., C.Y.G., D.L.B., Z.H., S.W.B.), University of Texas Medical Branch, Galveston, Tex; Institute of Toxicology and Environmental Health (D.U., K.E.P.), University of California, Davis; and Children's Hospital of Philadelphia (H.I.), Abramson Pediatric Research Center, Philadelphia, Pa. * To whom correspondence should be addressed. E-mail: swballin{at}utmb.edu.
Background—A
shared feature among cardiovascular disease risk
factors is increased oxidative stress. Because mitochondria are
susceptible to damage mediated by oxidative stress, we hypothesized
that risk factors (secondhand smoke and
hypercholesterolemia) are associated with
increased mitochondrial damage in cardiovascular
tissues. Methods and Results—Atherosclerotic lesion formation,
mitochondrial DNA damage, protein nitration, and specific activities of
mitochondrial proteins in cardiovascular tissues from
age-matched C57 and apoE-/- mice exposed
to filtered air or secondhand smoke were quantified. Both secondhand
smoke and hypercholesterolemia were associated
with significantly increased mitochondrial DNA damage and protein
nitration. Tobacco smoke exposure also resulted in significantly
decreased specific activities of mitochondrial enzymes. The combination
of secondhand smoke and hypercholesterolemia
resulted in increased atherosclerotic lesion formation and even greater
levels of mitochondrial damage. Conclusions—These data
are consistent with the hypothesis that
cardiovascular disease risk factors cause mitochondrial
damage and dysfunction.
Accepted on December 19, 2001
Cigarette Smoke Exposure and
Hypercholesterolemia Increase Mitochondrial
Damage in Cardiovascular Tissues
Key words: atherosclerosis • smoking • hypercholesterolemia • mitochondria
This article has been cited by other articles:
 |
|
 |
|
  D. Tan, D. S. Goerlitz, R. G. Dumitrescu, D. Han, F. Seillier-Moiseiwitsch, S. M. Spernak, R. A. Orden, J. Chen, R. Goldman, and P. G. Shields Associations between cigarette smoking and mitochondrial DNA abnormalities in buccal cells Carcinogenesis, June 1, 2008; 29(6): 1170 - 1177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Csiszar, N. Labinskyy, A. Podlutsky, P. M. Kaminski, M. S. Wolin, C. Zhang, P. Mukhopadhyay, P. Pacher, F. Hu, R. de Cabo, et al. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2721 - H2735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. An, H. Wang, P. Song, M. Zhang, X. Geng, and M.-H. Zou Nicotine-induced Activation of AMP-activated Protein Kinase Inhibits Fatty Acid Synthase in 3T3L1 Adipocytes: A ROLE FOR OXIDANT STRESS J. Biol. Chem., September 14, 2007; 282(37): 26793 - 26801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Barbieri and B. B. Weksler Tobacco smoke cooperates with interleukin-1{beta} to alter {beta}-catenin trafficking in vascular endothelium resulting in increased permeability and induction of cyclooxygenase-2 expression in vitro and in vivo FASEB J, June 1, 2007; 21(8): 1831 - 1843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. R. Madamanchi and M. S. Runge Mitochondrial Dysfunction in Atherosclerosis Circ. Res., March 2, 2007; 100(4): 460 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Bailey, G. Robinson, A. Pinner, L. Chamlee, E. Ulasova, M. Pompilius, G. P. Page, D. Chhieng, N. Jhala, A. Landar, et al. S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver Am J Physiol Gastrointest Liver Physiol, November 1, 2006; 291(5): G857 - G867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gutierrez, S. W. Ballinger, V. M. Darley-Usmar, and A. Landar Free Radicals, Mitochondria, and Oxidized Lipids: The Emerging Role in Signal Transduction in Vascular Cells Circ. Res., October 27, 2006; 99(9): 924 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bartecchi, R. N. Alsever, C. Nevin-Woods, W. M. Thomas, R. O. Estacio, B. B. Bartelson, and M. J. Krantz Reduction in the Incidence of Acute Myocardial Infarction Associated With a Citywide Smoking Ordinance Circulation, October 3, 2006; 114(14): 1490 - 1496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Storz Reactive Oxygen Species-Mediated Mitochondria-to-Nucleus Signaling: A Key to Aging and Radical-Caused Diseases Sci. Signal., April 25, 2006; 2006(332): re3 - re3. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Vartanian, B. Lowell, I. G. Minko, T. G. Wood, J. D. Ceci, S. George, S. W. Ballinger, C. L. Corless, A. K. McCullough, and R. S. Lloyd The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase PNAS, February 7, 2006; 103(6): 1864 - 1869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. Masayesva, E. Mambo, R. J. Taylor, O. G. Goloubeva, S. Zhou, Y. Cohen, K. Minhas, W. Koch, J. Sciubba, A. J. Alberg, et al. Mitochondrial DNA Content Increase in Response to Cigarette Smoking Cancer Epidemiol. Biomarkers Prev., January 1, 2006; 15(1): 19 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Barnoya and S. A. Glantz Cardiovascular Effects of Secondhand Smoke: Nearly as Large as Smoking Circulation, May 24, 2005; 111(20): 2684 - 2698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Maresh, H. Xu, N. Jiang, C. G. Gairola, and R. V. Shohet Tobacco smoke dysregulates endothelial vasoregulatory transcripts in vivo Physiol Genomics, May 11, 2005; 21(3): 308 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Young, C. A. Knight, K. C. Vickers, D. Westbrook, N. R. Madamanchi, M. S. Runge, H. Ischiropoulos, and S. W. Ballinger Differential effects of exercise on aortic mitochondria Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1683 - H1689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. R. Madamanchi, A. Vendrov, and M. S. Runge Oxidative Stress and Vascular Disease Arterioscler. Thromb. Vasc. Biol., January 1, 2005; 25(1): 29 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Yang, C. A. Knight, M. M. Mamerow, K. Vickers, A. Penn, E. M. Postlethwait, and S. W. Ballinger Prenatal Environmental Tobacco Smoke Exposure Promotes Adult Atherogenesis and Mitochondrial Damage in Apolipoprotein E-/- Mice Fed a Chow Diet Circulation, December 14, 2004; 110(24): 3715 - 3720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Recinos III, B. K. Carr, D. B. Bartos, I. Boldogh, J. R. Carmical, L. M. Belalcazar, and A. R. Brasier Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway Physiol Genomics, September 16, 2004; 19(1): 131 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Venkatraman, A. Landar, A. J. Davis, L. Chamlee, T. Sanderson, H. Kim, G. Page, M. Pompilius, S. Ballinger, V. Darley-Usmar, et al. Modification of the Mitochondrial Proteome in Response to the Stress of Ethanol-dependent Hepatotoxicity J. Biol. Chem., May 21, 2004; 279(21): 22092 - 22101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bhatnagar Cardiovascular pathophysiology of environmental pollutants Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H479 - H485. [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Lightfoot, S. Khov, and H. Ischiropoulos Transient injury to rat lung mitochondrial DNA after exposure to hyperoxia and inhaled nitric oxide Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L23 - L29. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. V. Turko and F. Murad Protein Nitration in Cardiovascular Diseases Pharmacol. Rev., December 1, 2002; 54(4): 619 - 634. [Abstract] [Full Text] [PDF]
|
|