Published Online
on December 31, 2001

A more recent version of this article appeared on February 12, 2002

This Article Full Text (PDF) All Versions of this Article: 105/6/714    most recent hc0602.103585v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Okin, P. M. Articles by Howard, B. V. Search for Related Content PubMed Articles by Okin, P. M. Articles by Howard, B. V. Related Collections Epidemiology Electrocardiology

Submitted on October 1, 2001
Revised on November 20, 2001
Accepted on December 14, 2001

Principal Component Analysis of the T Wave and Prediction of Cardiovascular Mortality in American Indians. The Strong Heart Study

Peter M. Okin MD^*, Richard B. Devereux MD, Richard R. Fabsitz MA, Elisa T. Lee PhD, James M. Galloway MD, and Barbara V. Howard PhD

From the Division of Cardiology, Department of Medicine (P.M.O., R.B.D.), Cornell Medical Center, New York, NY; National Heart, Lung, and Blood Institute (R.R.F.), Bethesda, Md; College of Public Health, University of Oklahoma Health Sciences Center (E.L.T.), Oklahoma City, Okla; University of Arizona (J.M.G.), Tucson, AZ; and Medlantic Research Institute (B.V.H.), Washington, DC.

^* To whom correspondence should be addressed. E-mail: pokin{at}med.cornell.edu.

Background—Increased QT interval dispersion (QTd) is a proposed ECG marker of vulnerability to ventricular arrhythmias and of cardiovascular (CV) mortality. However, principal component analysis (PCA) of the T-wave vector loop may more accurately represent repolarization abnormalities than QTd.

Methods and Results—Predictive values of QTd and PCA were assessed in 1839 American Indian participants in the first Strong Heart Study examination. T-wave loop morphology was quantified by the ratio of the second to first eigenvalues of the T-wave vector by PCA (PCA ratio); QTd was quantified as the difference between maximum and minimum QT intervals. After 3.7±0.9 years mean follow-up, there were 55 CV deaths. In univariate analyses, an increased PCA ratio predicted CV mortality in women (²=7.8, P=0.0053) and men (²=9.5, P=0.0021). In contrast, increased QTd was a significant predictor of CV mortality in women (²=30.6, P<0.0001) but not in men (²=2.0, P=NS). In multivariate Cox analyses controlling for risk factors and rate-corrected QT interval, the PCA ratio remained a significant predictor of CV mortality in women (²=4.0, P=0.043) and men (²=6.4, P=0.011); QTd was a significant predictor in women only (²=11.0, P=0.0009). PCA ratios >90th percentile (32% in women and 24.6% in men) identified women with a 3.68-fold increased risk of CV mortality (95% CI, 1.54 to 8.83) and men with a 2.77-fold increased risk (95% CI, 1.18 to 6.49).

Conclusions—Abnormalities of repolarization measured by PCA of the T-wave loop predict CV death in men and women, supporting use of PCA for quantifying repolarization abnormalities.

Key words: electrocardiography • epidemiology • mortality • prognosis

This article has been cited by other articles:

				H. Mueller, M. U. Kassack, and M. Wiese Comparison of the Usefulness of the MTT, ATP, and Calcein Assays to Predict the Potency of Cytotoxic Agents in Various Human Cancer Cell Lines J Biomol Screen, September 1, 2004; 9(6): 506 - 515. [Abstract] [PDF]

				P. M. Okin QT interval prolongation and prognosis: further validation of the quantitative approach to electrocardiography J. Am. Coll. Cardiol., February 18, 2004; 43(4): 572 - 575. [Full Text] [PDF]

				P. M. Okin, R. B. Devereux, E. T. Lee, J. M. Galloway, and B. V. Howard Electrocardiographic Repolarization Complexity and Abnormality Predict All-Cause and Cardiovascular Mortality in Diabetes: The Strong Heart Study Diabetes, February 1, 2004; 53(2): 434 - 440. [Abstract] [Full Text]

				P. Smetana, V. N. Batchvarov, K. Hnatkova, A. J. Camm, and M. Malik Ventricular gradient and nondipolar repolarization components increase at higher heart rate Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H131 - H136. [Abstract] [Full Text] [PDF]